The fin-to-limb transition as the re-organization of a Turing pattern

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• dc.contributor.author Onimaru, Kohca
• dc.contributor.author Marcon, Luciano, 1983-ca
• dc.contributor.author Musy, Marcoca
• dc.contributor.author Tanaka, Mikikoca
• dc.contributor.author Sharpe, Jamesca
• dc.date.accessioned 2017-01-25T07:42:29Z
• dc.date.available 2017-01-25T07:42:29Z
• dc.date.issued 2016ca
• dc.description.abstract A Turing mechanism implemented by BMP, SOX9 and WNT has been proposed to control mouse digit patterning. However, its generality and contribution to the morphological diversity of fins and limbs has not been explored. Here we provide evidence that the skeletal patterning of the catshark Scyliorhinus canicula pectoral fin is likely driven by a deeply conserved Bmp–Sox9–Wnt Turing network. In catshark fins, the distal nodular elements arise from a periodic spot pattern of Sox9 expression, in contrast to the stripe pattern in mouse digit patterning. However, our computer model shows that the Bmp–Sox9–Wnt network with altered spatial modulation can explain the Sox9 expression in catshark fins. Finally, experimental perturbation of Bmp or Wnt signalling in catshark embryos produces skeletal alterations which match in silico predictions. Together, our results suggest that the broad morphological diversity of the distal fin and limb elements arose from the spatial re-organization of a deeply conserved Turing mechanism.
• dc.description.sponsorship This work was supported by the Spanish Ministry of Economy and Competitiveness, through ‘Centro de Excelencia Severo Ochoa 2013–2017’, SEV-2012-0208, and the Plan Nacional grant BFU2010-16428 and BFU2015-68725-P (co-financed by FEDER funds of the European commissions) to K.O., L.M., M.M. and J.S., and by ICREA to J.S. and in part by the Global COE Program ‘Evolving Education and Research Center for Spatio-Temporal Biological Network’ from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) and the Program for Leading Graduate Schools ‘Education Academy of Computational Life Sciences’ from the MEXT to K.O. and M.T., the Grant-in-Aid for Scientific Research (B) 25291086 and the Inamori Foundation to M.T.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Onimaru K, Marcon L, Musy M, Tanaka M, Sharpe J. The fin-to-limb transition as the re-organization of a Turing pattern. Nature Communications. 2016; 7: 11582. DOI: 10.1038/ncomms11582ca
• dc.identifier.doi http://dx.doi.org/10.1038/ncomms11582
• dc.identifier.issn 2041-1723ca
• dc.identifier.uri http://hdl.handle.net/10230/27975
• dc.language.iso engca
• dc.publisher Nature Publishing Groupca
• dc.relation.ispartof Nature Communications. 2016;7:11582
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2010-16428
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SEV2012-0208
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-68725-P
• dc.rights © Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Computer modelling
• dc.subject.keyword Evolution
• dc.subject.keyword Morphogenesis
• dc.title The fin-to-limb transition as the re-organization of a Turing patternca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca