Research recommendations for selected IARC-classified agents: impact and lessons learned

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  • dc.contributor.author Turner, Michelle C.
  • dc.contributor.author Cogliano, Vincent
  • dc.contributor.author Guyton, Kathryn
  • dc.contributor.author Madia, Federica
  • dc.contributor.author Straif, Kurt
  • dc.contributor.author Ward, Elizabeth M.
  • dc.contributor.author Schubauer-Berigan, Mary K.
  • dc.date.accessioned 2024-02-15T07:10:37Z
  • dc.date.available 2024-02-15T07:10:37Z
  • dc.date.issued 2023
  • dc.description.abstract Background: The International Agency for Research on Cancer (IARC) Monographs program assembles expert working groups who publish a critical review and evaluation of data on agents of interest. These comprehensive reviews provide a unique opportunity to identify research needs to address classification uncertainties. A multidisciplinary expert review and workshop held in 2009 identified research gaps and needs for 20 priority occupational chemicals, metals, dusts, and physical agents, with the goal of stimulating advances in epidemiological studies of cancer and carcinogen mechanisms. Overarching issues were also described. Objectives: In this commentary we review the current status of the evidence for the 20 priority agents identified in 2009. We examine whether identified Research Recommendations for each agent were addressed and their potential impact on resolving classification uncertainties. Methods: We reviewed the IARC classifications of each of the 20 priority agents and identified major new epidemiological and human mechanistic studies published since the last evaluation. Information sources were either the published Monograph for agents that have been reevaluated or, for agents not yet reevaluated, Advisory Group reports and literature searches. Findings are described in view of recent methodological developments in Monographs evidence evaluation processes. Discussion: The majority of the 20 priority agents were reevaluated by IARC since 2009. The overall carcinogen classifications of 9 agents advanced, and new cancer sites with either "sufficient" or "limited" evidence of carcinogenicity were also identified for 9 agents. Examination of published findings revealed whether evidence gaps and Research Recommendations have been addressed and highlighted remaining uncertainties. During the past decade, new research addressed a range of the 2009 recommendations and supported updated classifications for priority agents. This supports future efforts to systematically apply findings of Monograph reviews to identify research gaps and priorities relevant to evaluation criteria established in the updated IARC Monograph Preamble. https://doi.org/10.1289/EHP12547.
  • dc.description.sponsorship M.C.T. is funded by a Ramón y Cajal fellowship (RYC-2017-01892) from the Spanish Ministry of Science, Innovation and Universities and co-funded by the European Social Fund. The Barcelona Institute for Global Health (ISGlobal) acknowledges support from the Spanish Ministry of Science and Innovation through the Centro de Excelencia Severo Ochoa 2019–2023 Program (CEX2018-000806-S) and support from the Generalitat de Catalunya through the Centres de Recerca de Catalunya (CERCA) Program. The IARC Monographs programme receives funding from the National Cancer Institute (3U01CA033193-38S1).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Turner MC, Cogliano V, Guyton K, Madia F, Straif K, Ward EM, Schubauer-Berigan MK. Research recommendations for selected IARC-classified agents: impact and lessons learned. Environ Health Perspect. 2023 Oct;131(10):105001. DOI: 10.1289/EHP12547
  • dc.identifier.doi http://dx.doi.org/10.1289/EHP12547
  • dc.identifier.issn 0091-6765
  • dc.identifier.uri http://hdl.handle.net/10230/59112
  • dc.language.iso eng
  • dc.publisher National Institute of Environmental Health Sciences (NIEHS)
  • dc.relation.ispartof Environ Health Perspect. 2023 Oct;131(10):105001
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RYC-2017-01892
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
  • dc.rights Reproduced with permission from Environmental Health Perspectives
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.other Càncer--Investigació
  • dc.title Research recommendations for selected IARC-classified agents: impact and lessons learned
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)