Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis.

Ortiz, Miguel A.; Núñez, Concepción; Ordóñez, David; Álvarez Cermeño, Jose Carlos; Martínez-Rodriguez, José E.; Sánchez, Antonio J.; Arroyo, Rafael; Izquierdo, Guillermo; Malhotra, Sunny, 1984-; Montalbán Gairín, Xavier; García Merino, Antonio; Munteis Olivas, Elvira; Alcina, Antonio; Comabella López, Manuel; Matesanz, Fuencisla; Villar, Luisa Maria; Urcelay, Elena

Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis.

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dc.contributor.author Ortiz, Miguel A.ca
dc.contributor.author Núñez, Concepciónca
dc.contributor.author Ordóñez, Davidca
dc.contributor.author Álvarez Cermeño, Jose Carlosca
dc.contributor.author Martínez-Rodriguez, José E.ca
dc.contributor.author Sánchez, Antonio J.ca
dc.contributor.author Arroyo, Rafaelca
dc.contributor.author Izquierdo, Guillermoca
dc.contributor.author Malhotra, Sunny, 1984-ca
dc.contributor.author Montalbán Gairín, Xavierca
dc.contributor.author García Merino, Antonioca
dc.contributor.author Munteis Olivas, Elviraca
dc.contributor.author Alcina, Antonioca
dc.contributor.author Comabella López, Manuelca
dc.contributor.author Matesanz, Fuencislaca
dc.contributor.author Villar, Luisa Mariaca
dc.contributor.author Urcelay, Elenaca
dc.date.accessioned 2015-10-08T06:50:33Z
dc.date.available 2015-10-08T06:50:33Z
dc.date.issued 2015
dc.description.abstract BACKGROUND: Multiple sclerosis (MS) is a neurodegenerative, autoimmune disease of the central nervous system. Genome-wide association studies (GWAS) have identified over hundred polymorphisms with modest individual effects in MS susceptibility and they have confirmed the main individual effect of the Major Histocompatibility Complex. Additional risk loci with immunologically relevant genes were found significantly overrepresented. Nonetheless, it is accepted that most of the genetic architecture underlying susceptibility to the disease remains to be defined. Candidate association studies of the leukocyte immunoglobulin-like receptor LILRA3 gene in MS have been repeatedly reported with inconsistent results. OBJECTIVES: In an attempt to shed some light on these controversial findings, a combined analysis was performed including the previously published datasets and three newly genotyped cohorts. Both wild-type and deleted LILRA3 alleles were discriminated in a single-tube PCR amplification and the resulting products were visualized by their different electrophoretic mobilities. RESULTS AND CONCLUSION: Overall, this meta-analysis involved 3200 MS patients and 3069 matched healthy controls and it did not evidence significant association of the LILRA3 deletion [carriers of LILRA3 deletion: p = 0.25, OR (95% CI) = 1.07 (0.95-1.19)], even after stratification by gender and the HLA-DRB1*15:01 risk allele.ca
dc.description.sponsorship Financial support for the study was provided by: Fondo de Investigación Sanitaria (FIS)- Instituto de Salud Carlos III (ISCIII)-Fondos Europeos de Desarrollo Regional (FEDER) (grant numbers PI12/00555 to FM; PI13/01527 to AA; PI13/01466 to GI; PI13/0879 to EU and RETICS-REEM RD12/0032/ ) and Junta de Andalucía (JA)- Fondos Europeos de Desarrollo Regional (FEDER) (grant number CTS2704 to FM)
dc.format.mimetype application/pdfca
dc.identifier.citation Ortiz MA, Núñez C, Ordóñez D, Alvarez-Cermeño JC, Martínez-Rodriguez JE, Sánchez AJ. et al. Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis. PLoS One. 2015 Aug 14;10(8):e0134414. doi: 10.1371/journal.pone.0134414.ca
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0134414
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/24820
dc.language.iso engca
dc.publisher Public Library of Scienceca
dc.relation.ispartof PLoS One. 2015 Aug 14;10(8):e0134414
dc.rights © 2015 Ortiz et al. This is an openaccess article distributed under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source arecreditedca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
dc.subject.other Esclerosi múltipleca
dc.subject.other Malalties autoimmunitàriesca
dc.title Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis.ca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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