Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain

Villanueva Belmonte, Cristina; Gracia Lavedan, Esther; Ibarluzea, Jesús; Marina, Loreto Santa; Ballester Díez, Ferran; Llop, Sabrina; Tardón, Adonina; Fernandez, Mariana F.; Freire, Carmen; Goñi, Fernando; Basagaña Flores, Xavier; Kogevinas, Manolis; Grimalt Obrador, Joan; Sunyer Deu, Jordi

Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain

Mostra el registre complet Registre parcial de l'ítem

dc.contributor.author Villanueva Belmonte, Cristinaca
dc.contributor.author Gracia Lavedan, Estherca
dc.contributor.author Ibarluzea, Jesúsca
dc.contributor.author Marina, Loreto Santaca
dc.contributor.author Ballester Díez, Ferranca
dc.contributor.author Llop, Sabrinaca
dc.contributor.author Tardón, Adoninaca
dc.contributor.author Fernandez, Mariana F.ca
dc.contributor.author Freire, Carmenca
dc.contributor.author Goñi, Fernandoca
dc.contributor.author Basagaña Flores, Xavierca
dc.contributor.author Kogevinas, Manolisca
dc.contributor.author Grimalt Obrador, Joanca
dc.contributor.author Sunyer Deu, Jordica
dc.date.accessioned 2015-04-08T10:15:01Z
dc.date.available 2015-04-08T10:15:01Z
dc.date.issued 2011ca
dc.description.abstract Background: Evidence associating exposure to water disinfection by-products with reduced birth weight and altered duration of gestation remains inconclusive. Objective: We assessed exposure to trihalomethanes (THMs) during pregnancy through different water uses and evaluated the association with birth weight, small for gestational age (SGA), low birth weight (LBW), and preterm delivery. Methods: Mother–child cohorts set up in five Spanish areas during the years 2000–2008 contributed data on water ingestion, showering, bathing, and swimming in pools. We ascertained residential THM levels during pregnancy periods through ad hoc sampling campaigns (828 measurements) and regulatory data (264 measurements), which were modeled and combined with personal water use and uptake factors to estimate personal uptake. We defined outcomes following standard definitions and included 2,158 newborns in the analysis. Results: Median residential THM ranged from 5.9 μg/L (Valencia) to 114.7 μg/L (Sabadell), and speciation differed across areas. We estimated that 89% of residential chloroform and 96% of brominated THM uptakes were from showering/bathing. The estimated change of birth weight for a 10% increase in residential uptake was –0.45 g (95% confidence interval: –1.36, 0.45 g) for chloroform and 0.16 g (–1.38, 1.70 g) for brominated THMs. Overall, THMs were not associated with SGA, LBW, or preterm delivery. Conclusions: Despite the high THM levels in some areas and the extensive exposure assessment, results suggest that residential THM exposure during pregnancy driven by inhalation and dermal contact routes is not associated with birth weight, SGA, LBW, or preterm delivery in Spain.en
dc.description.sponsorship This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041; from Fondo de Investigación Sanitaria (FIS): FIS-FEDER (Fondo Europeo de Desarrollo Regional) 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647, PI080533, FIS-PI041436, FIS-PI06/0867, FIS-PI081151, FIS-S09-PS09/02311); CIBER (AA08_012); Generalitat de Catalunya-CIRIT (1999SGR 00241); Departamento de Sanidad del Gobierno Vasco (BIOEF06/002); Diputación Foral de Gipuzkoa (DFG06/004); Consejería de Salud, Junta de Andalucía (PI-0183/2007); Conselleria de Sanitat Generalitat Valenciana; Fundació Roger Torné; and HI-WATE (Health Impacts of Long-Term Exposure to Disinfection By-Products in Drinking Water) project (FP6-2005-FOOD-4B, reg. 036224)en
dc.format.mimetype application/pdfca
dc.identifier.citation Villanueva CM, Gracia-Lavedan E, Ibarluzea J, Marina LS, Ballester F, Llop S et al. Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain. Environ Health Perspect. 2011;119(12):1824-30. DOI: 10.1289/ehp.1002425ca
dc.identifier.doi http://dx.doi.org/10.1289/ehp.1002425
dc.identifier.issn 0091-6765ca
dc.identifier.uri http://hdl.handle.net/10230/23358
dc.language.iso engca
dc.publisher National Institute of Environmental Health Sciences (NIEHS)ca
dc.relation.ispartof Environmental Health Perspectives. 2011;119(12):1824-30
dc.rights Reproduced with permission from Environmental Health Perspectivesca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.subject.keyword Birth weighten
dc.subject.keyword Cohort studyen
dc.subject.keyword Disinfection by-productsen
dc.subject.keyword Epidemiologyen
dc.subject.keyword Low birth weighten
dc.subject.keyword Newbornen
dc.subject.keyword Premature birthen
dc.subject.keyword Small for gestational ageen
dc.subject.keyword Trihalomethanesen
dc.subject.keyword Water pollutionen
dc.subject.other Infeccions respiratòries -- Epidemiologiaca
dc.subject.other Aigua -- Depuracióca
dc.subject.other Fetus -- Creixementca
dc.subject.other Embaràs -- Aspectes nutricionalsca
dc.subject.other Epidemiologiaca
dc.title Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spainen
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Hospital del Mar Research Institute)