The quest for a message: budding yeast, a model organism to study the control of pre-mRNA splicing

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• dc.contributor.author Meyer, Markusca
• dc.contributor.author Vilardell, Josepca
• dc.date.accessioned 2012-04-18T13:52:01Z
• dc.date.available 2012-04-18T13:52:01Z
• dc.date.issued 2009ca
• dc.description.abstract Removal of introns during pre-mRNA splicing is a critical process in gene expression, and understanding its control at both single-gene and genomic levels is one of the great challenges in Biology. Splicing takes place in a dynamic, large ribonucleoprotein complex known as the spliceosome. Combining Genetics and Biochemistry, Saccharomyces cerevisiae provides insights into its mechanisms, including its regulation by RNA-protein interactions. Recent genome-wide analyses indicate that regulated splicing is broad and biologically relevant even in organisms with a relatively simple intronic structure, such as yeast. Furthermore, the possibility of coordination in splicing regulation at genomic level is becoming clear in this model organism. This should provide a valuable system to approach the complex problem of the role of regulated splicing in genomic expression.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Meyer M, Vilardell J. The quest for a message: budding yeast, a model organism to study the control of pre-mRNA splicing. Brief Funct Genomic Proteomic. 2009;8(1):60-7. DOI: 10.1093/bfgp/elp002ca
• dc.identifier.doi http://dx.doi.org/10.1093/bfgp/elp002
• dc.identifier.issn 1473-9550ca
• dc.identifier.uri http://hdl.handle.net/10230/16373
• dc.language.iso engca
• dc.publisher Oxford University Pressca
• dc.relation.ispartof Briefings in Functional Genomics and Proteomics. 2009;8(1):60-7
• dc.rights © 2009 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Briefings in Functional Genomics and Proteomics following peer review. The definitive publisher-authenticated version Meyer M, Vilardell J. The quest for a message: budding yeast, a model organism to study the control of pre-mRNA splicing. Brief Funct Genomic Proteomic. 2009; 8(1):60-7 is available online at: http://bfg.oxfordjournals.org/content/8/1/60.longca
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Regulated splicing
• dc.subject.keyword RNA
• dc.subject.keyword Yeast
• dc.subject.keyword Genomics
• dc.subject.keyword Microarrays
• dc.subject.other ARN empalmament
• dc.subject.other Regulació genètica
• dc.title The quest for a message: budding yeast, a model organism to study the control of pre-mRNA splicingca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/acceptedVersion