DNA methylation and high-density lipoprotein functionality-brief report: The REGICOR study (Registre Gironi del Cor)
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Sayols Baixeras, Sergi, 1988-
- dc.contributor.author Hernáez, Álvaro
- dc.contributor.author Subirana Cachinero, Isaac
- dc.contributor.author Lluís Ganella, Carla, 1984-
- dc.contributor.author Muñoz Aguayo, Daniel
- dc.contributor.author Fitó Colomer, Montserrat
- dc.contributor.author Marrugat de la Iglesia, Jaume
- dc.contributor.author Elosua Llanos, Roberto
- dc.date.accessioned 2024-01-24T17:03:18Z
- dc.date.available 2024-01-24T17:03:18Z
- dc.date.issued 2017
- dc.description.abstract Objective: The function of high-density lipoproteins (HDLs) may better reflect their atheroprotective role, compared with HDL-cholesterol levels. The association between DNA methylation and HDL function has not yet been established. Approach and results: We designed an epigenome-wide association study including 645 individuals from the REGICOR study (Registre Gironi del Cor). We determined DNA methylation from peripheral blood cells using the HumanMethylation450 array. We analyzed HDL functionality by determining HDL cholesterol efflux capacity and HDL inflammatory index. We discovered 3 methylation sites located in HOXA3, PEX5, and PER3 related to cholesterol efflux capacity and 1 located in GABRR1 related to HDL inflammatory index. Using a candidate gene approach, we also found 2 methylation sites located in CMIP related to cholesterol efflux capacity. Conclusions: We identified 6 potential loci associated with HDL functionality in HOXA3, PEX5, PER3, CMIP, and GABRR1. Additional studies are warranted to validate these findings in other populations.
- dc.format.mimetype application/pdf
- dc.identifier.citation Sayols-Baixeras S, Hernáez A, Subirana I, Lluis-Ganella C, Muñoz D, Fitó M, Marrugat J, Elosua R. DNA methylation and high-density lipoprotein functionality-brief report: The REGICOR study (Registre Gironi del Cor). Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):567-9. DOI: 10.1161/ATVBAHA.116.308831
- dc.identifier.doi http://dx.doi.org/10.1161/ATVBAHA.116.308831
- dc.identifier.issn 1079-5642
- dc.identifier.uri http://hdl.handle.net/10230/58813
- dc.language.iso eng
- dc.publisher American Hearth Association
- dc.relation.ispartof Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):567-9
- dc.rights © American Hearth Association http://dx.doi.org/10.1161/ATVBAHA.116.308831
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword DNA methylation
- dc.subject.keyword Atherosclerosis
- dc.subject.keyword Blood cells
- dc.subject.keyword Lipoproteins
- dc.subject.keyword Risk factors
- dc.title DNA methylation and high-density lipoprotein functionality-brief report: The REGICOR study (Registre Gironi del Cor)
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion