Open problems in synthetic multicellularity

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  • dc.contributor.author Solé Vicente, Ricard, 1962-
  • dc.contributor.author Conde Pueyo, Núria, 1983-
  • dc.contributor.author Pla, Jordi
  • dc.contributor.author García Ojalvo, Jordi
  • dc.contributor.author Montserrat Pulido, Núria
  • dc.contributor.author Levin, Michael
  • dc.date.accessioned 2025-02-21T07:15:49Z
  • dc.date.available 2025-02-21T07:15:49Z
  • dc.date.issued 2024
  • dc.description.abstract Multicellularity is one of the major evolutionary transitions, and its rise provided the ingredients for the emergence of a biosphere inhabited by complex organisms. Over the last decades, the potential for bioengineering multicellular systems has been instrumental in interrogating nature and exploring novel paths to regeneration, disease, cognition, and behaviour. Here, we provide a list of open problems that encapsulate many of the ongoing and future challenges in the field and suggest conceptual approaches that may facilitate progress.
  • dc.description.sponsorship R.S., N.C., and J.P.M. thank the members of the Complex Systems Lab for useful discussions and Aurora Picornell for her inspiring ideas. This work has been supported by an AGAUR 2021 SGR 0075 grant and the Santa Fe Institute. J.P.M. was supported by funding from the Spanish government “PRE2020-091968” (MCIN/AEI) grant. J.G.O. was supported by the Spanish Ministry of Science and Innovation, the Spanish State Research Agency and FEDER (project PID2021-127311NB-I00), by the Maria de Maeztu Programme for Units of Excellence in R&D (project CEX2018-000792-M), and by the ICREA Academia programme. This work has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program ERCCoG-2020 101002478 ENGINORG to N.M. M.L. gratefully acknowledges the support of Grant 62212 from the John Templeton Foundation and Grant Number W911NF-23-1-0100 from the Army Research Office. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Office or the U.S. Government.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Solé R, Conde-Pueyo N, Pla-Mauri J, Garcia-Ojalvo J, Montserrat N, Levin M. Open problems in synthetic multicellularity. NPJ Syst Biol Appl. 2024 Dec 31;10(1):151. DOI: 10.1038/s41540-024-00477-8
  • dc.identifier.doi http://dx.doi.org/10.1038/s41540-024-00477-8
  • dc.identifier.issn 2056-7189
  • dc.identifier.uri http://hdl.handle.net/10230/69672
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof NPJ Syst Biol Appl. 2024 Dec 31;10(1):151
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101002478
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PRE2020-091968
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2021-127311NB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000792-M
  • dc.rights © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Multicellular systems
  • dc.subject.keyword Synthetic biology
  • dc.title Open problems in synthetic multicellularity
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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