Strategies to enhance management of HER2-positive breast cancer in the elderly: an expert consensus perspective

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• dc.contributor.author del Barco, Sonia
• dc.contributor.author Cotes Sanchís, Almudena
• dc.contributor.author Cavanagh, Mercedes
• dc.contributor.author Gironés i Sarrió, Regina
• dc.contributor.author López de San Vicente Hernández, Borja
• dc.contributor.author Galve Calvo, Elena
• dc.contributor.author Servitja Tormo, Sonia
• dc.date.accessioned 2025-10-24T17:15:08Z
• dc.date.available 2025-10-24T17:15:08Z
• dc.date.issued 2025
• dc.date.updated 2025-10-24T17:15:08Z
• dc.description.abstract Therapeutic decision-making for older patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer highlights the importance of a comprehensive geriatric assessment (CGA). This assessment considers the functional status, comorbidities, and relevant conditions of the patient, and allows for an estimation of life expectancy, but it does not facilitate individualized treatment plans. There are also other challenges to consider related to the cardiac toxicity of the treatments and the under-representation of older patients in clinical trials. The Oncogeriatrics Section of the Spanish Society of Medical Oncology (Sociedad Española de Oncología Médica, SEOM), the Spanish Group for Breast Cancer Research (Grupo Español de Investigación en Cáncer de Mama, GEICAM) and the Spanish Group of Study, Treatment and other Experimental Strategies in Solid Tumours (Grupo Español de Estudio, Tratamiento y otras Estrategias Experimentales en Tumores Sólidos, SOLTI) have gathered an expert committee to evaluate the scientific evidence on the management of older patients with HER2-positive breast cancer and to establish recommendations based on a comprehensive review of the existing literature. These recommendations underscore the importance of individualizing treatment plans based on the patient's physical status and tolerability to maximize efficacy while minimizing toxicity. Emphasis is placed on adapting neoadjuvant and adjuvant therapies according to geriatric assessment and specific patient needs. A careful selection of treatment schedules for advanced stages is needed to improve survival and quality of life, assuming that scientific evidence in this age group is limited.
• dc.format.mimetype application/pdf
• dc.identifier.citation Del Barco S, Cotes-Sanchís A, Cavanagh M, Gironés-Sarrió R, de San Vicente BL, Galve-Calvo E, Servitja S. Strategies to enhance management of HER2-positive breast cancer in the elderly: an expert consensus perspective. Clin Transl Oncol. 2025 Jul;27(7):2955-69. DOI: 10.1007/s12094-024-03838-1
• dc.identifier.doi http://dx.doi.org/10.1007/s12094-024-03838-1
• dc.identifier.issn 1699-048X
• dc.identifier.uri http://hdl.handle.net/10230/71658
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Clinical and Translational Oncology. 2025;27(7):2955-69
• dc.rights © The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Breast cancer
• dc.subject.keyword Elderly patient
• dc.subject.keyword Geriatric assessment
• dc.subject.keyword HER2-positive
• dc.subject.keyword Toxicity
• dc.title Strategies to enhance management of HER2-positive breast cancer in the elderly: an expert consensus perspective
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion