Lifetime occupational exposure to metals and welding fumes, and risk of glioma: a 7-country population-based case-control study
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- dc.contributor.author Parent, Marie-Elise
- dc.contributor.author Turner, Michelle C.
- dc.contributor.author Figuerola, Jordi
- dc.contributor.author Cardis, Elisabeth
- dc.date.accessioned 2024-05-28T10:09:18Z
- dc.date.available 2024-05-28T10:09:18Z
- dc.date.issued 2017
- dc.description.abstract Background. Brain tumor etiology is poorly understood. Based on their ability to pass through the blood–brain barrier, it has been hypothesized that exposure to metals may increase the risk of brain cancer. Results from the few epidemiological studies on this issue are limited and inconsistent. Methods. We investigated the relationship between glioma risk and occupational exposure to five metals - lead, cadmium, nickel, chromium and iron- as well as to welding fumes, using data from the seven-country INTEROCC study. A total of 1800 incident glioma cases and 5160 controls aged 30–69 years were included in the analysis. Lifetime occupational exposure to the agents was assessed using the INTEROCC JEM, a modified version of the Finnish job exposure matrix FINJEM. Results. In general, cases had a slightly higher prevalence of exposure to the various metals and welding fumes than did controls, with the prevalence among ever exposed ranging between 1.7 and 2.2% for cadmium to 10.2 and 13.6% for iron among controls and cases, respectively. However, in multivariable logistic regression analyses, there was no association between ever exposure to any of the agents and risk of glioma with odds ratios (95% confidence intervals) ranging from 0.8 (0.7–1.0) for lead to 1.1 (0.7–1.6) for cadmium. Results were consistent across models considering cumulative exposure or duration, as well as in all sensitivity analyses conducted. Conclusions. Findings from this large-scale international study provide no evidence for an association between occupational exposure to any of the metals under scrutiny or welding fumes, and risk of glioma.
- dc.format.mimetype application/pdf
- dc.identifier.citation Parent M, Turner MC, Lavoué J, Richard H, Figuerola J, Kincl L, et al. Lifetime occupational exposure to metals and welding fumes, and risk of glioma: a 7-country population-based case–control study. Environ Health. 2017 Dec;16(1):90. DOI: 10.1186/s12940-017-0300-y
- dc.identifier.doi http://dx.doi.org/10.1186/s12940-017-0300-y
- dc.identifier.issn 1476-069X
- dc.identifier.uri http://hdl.handle.net/10230/60266
- dc.language.iso eng
- dc.publisher BioMed Central
- dc.relation.ispartof Environmental Health. 2017 Dec;16(1):90
- dc.rights This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Glioma
- dc.subject.keyword Occupational exposures
- dc.subject.keyword Metals
- dc.subject.keyword Welding fumes
- dc.title Lifetime occupational exposure to metals and welding fumes, and risk of glioma: a 7-country population-based case-control study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion