Telomere Length as a New Risk Marker of Early-Onset Colorectal Cancer

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  • dc.contributor.author Martel-Martel, Abel
  • dc.contributor.author Jiménez Toscano, Marta
  • dc.contributor.author González Sarmiento, Rogelio
  • dc.date.accessioned 2024-04-17T06:20:36Z
  • dc.date.available 2024-04-17T06:20:36Z
  • dc.date.issued 2023
  • dc.description.abstract Early-onset colorectal cancer (EOCRC; age younger than 50 years) incidence has been steadily increasing in recent decades worldwide. The need for new biomarkers for EOCRC prevention strategies is undeniable. In this study, we aimed to explore whether an aging factor, such as telomere length (TL), could be a useful tool in EOCRC screening. The absolute leukocyte TL from 87 microsatellite stable EOCRC patients and 109 healthy controls (HC) with the same range of age, was quantified by Real Time Quantitative PCR (RT-qPCR). Then, leukocyte whole-exome sequencing (WES) was performed to study the status of the genes involved in TL maintenance (hTERT, TERC, DKC1, TERF1, TERF2, TERF2IP, TINF2, ACD, and POT1) in 70 sporadic EOCRC cases from the original cohort. We observed that TL was significantly shorter in EOCRC patients than in healthy individuals (EOCRC mean: 122 kb vs. HC mean: 296 kb; p < 0.001), suggesting that telomeric shortening could be associated with EOCRC susceptibility. In addition, we found a significant association between several SNPs of hTERT (rs79662648), POT1 (rs76436625, rs10263573, rs3815221, rs7794637, rs7784168, rs4383910, and rs7782354), TERF2 (rs251796 and rs344152214), and TERF2IP (rs7205764) genes and the risk of developing EOCRC. We consider that the measurement of germline TL and the status analysis of telomere maintenance related genes polymorphisms at early ages could be non-invasive methods that could facilitate the early identification of individuals at risk of developing EOCRC.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Martel-Martel A, Corchete LA, Martí M, Vidal-Tocino R, Hurtado E, Álvaro E, et al. Telomere Length as a New Risk Marker of Early-Onset Colorectal Cancer. Int J Mol Sci. 2023 Feb 9;24(4):3526. DOI: 10.3390/ijms24043526
  • dc.identifier.doi http://dx.doi.org/DOI:10.3390/ijms24043526
  • dc.identifier.issn 1422-0067
  • dc.identifier.uri http://hdl.handle.net/10230/59803
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.ispartof Int J Mol Sci. 2023 Feb 9;24(4):3526
  • dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Colorectal cancer
  • dc.subject.keyword Early-onset colorectal cancer
  • dc.subject.keyword Risk
  • dc.subject.keyword Screening
  • dc.subject.keyword Telomere length
  • dc.title Telomere Length as a New Risk Marker of Early-Onset Colorectal Cancer
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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