Estimated whole-brain and lobe-specific radiofrequency electromagnetic fields doses and brain volumes in preadolescents

Cabré-Riera, Alba, 1991-; El Marroun, Hanan; Muetzel, Ryan L.; van Wel, Luuk; Liorni, Ilaria; Thielens, Arno; Birks, Laura Ellen, 1983-; Pierotti, Livia; Huss, Anke; Joseph, Wout; Wiart, Joe; Capstick, Myles; Hillegers, Manon; Vermeulen, Roel; Cardis, Elisabeth; Vrijheid, Martine; White, Tonya; Röösli, Martin; Tiemeier, Henning; Guxens Junyent, Mònica

doi:http://dx.doi.org/10.1016/j.envint.2020.105808

Estimated whole-brain and lobe-specific radiofrequency electromagnetic fields doses and brain volumes in preadolescents

Citation

Cabré-Riera A, Marroun HE, Muetzel R, van Wel L, Liorni I, Thielens A, Birks LE, Pierotti L, Huss A, Joseph W, Wiart J, Capstick M, Hillegers M, Vermeulen R, Cardis E, Vrijheid M, White T, Röösli M, Tiemeier H, Guxens M. Estimated whole-brain and lobe-specific radiofrequency electromagnetic fields doses and brain volumes in preadolescents. Environ Int. 2020; 142:105808. DOI: 10.1016/j.envint.2020.105808

Abstract

Objective: To assess the association between estimated whole-brain and lobe-specific radiofrequency electromagnetic fields (RF-EMF) doses, using an improved integrated RF-EMF exposure model, and brain volumes in preadolescents at 9-12 years old. Methods: Cross-sectional analysis in preadolescents aged 9-12 years from the Generation R Study, a population-based birth cohort set up in Rotterdam, The Netherlands (n = 2592). An integrated exposure model was used to estimate whole-brain and lobe-specific RF-EMF doses (mJ/kg/day) from different RF-EMF sources including mobile and Digital Enhanced Cordless Telecommunications (DECT) phone calls, other mobile phone uses than calling, tablet use, laptop use, and far-field sources. Whole-brain and lobe-specific RF-EMF doses were estimated for all RF-EMF sources together (i.e. overall) and for three groups of RF-EMF sources that lead to a different pattern of RF-EMF exposure. Information on brain volumes was extracted from magnetic resonance imaging scans. Results: Estimated overall whole-brain RF-EMF dose was 84.3 mJ/kg/day. The highest overall lobe-specific dose was estimated in the temporal lobe (307.1 mJ/kg/day). Whole-brain and lobe-specific RF-EMF doses from all RF-EMF sources together, from mobile and DECT phone calls, and from far-field sources were not associated with global, cortical, or subcortical brain volumes. However, a higher whole-brain RF-EMF dose from mobile phone use for internet browsing, e-mailing, and text messaging, tablet use, and laptop use while wirelessly connected to the internet was associated with a smaller caudate volume. Conclusions: Our results suggest that estimated whole-brain and lobe-specific RF-EMF doses were not related to brain volumes in preadolescents at 9-12 years old. Screen activities with mobile communication devices while wirelessly connected to the internet lead to low RF-EMF dose to the brain and our observed association may thus rather reflect effects of social or individual factors related to these specific uses of mobile communication devices. However, we cannot discard residual confounding, chance finding, or reverse causality. Further studies on mobile communication devices and their potential negative associations with brain development are warranted, regardless whether associations are due to RF-EMF exposure or to other factors related to their use.