Evolving AIDS- and non-AIDS mortality and predictors in the PISCIS cohort of people living with HIV in Catalonia and the Balearic Islands (Spain), 1998-2020

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Nomah, Daniel K.
  • dc.contributor.author Jamarkattel, Suju
  • dc.contributor.author Bruguera, Andreu
  • dc.contributor.author Moreno Fornés, Sergio
  • dc.contributor.author Díaz, Yesika
  • dc.contributor.author Alonso, Lucia
  • dc.contributor.author Aceitón Cardona, Jordi
  • dc.contributor.author Llibre, Josep M.
  • dc.contributor.author Domingo, Pere
  • dc.contributor.author Saumoy, Maria
  • dc.contributor.author Homar, Francesc
  • dc.contributor.author Fanjul, Francisco
  • dc.contributor.author Navarro Mercadé, Jordi
  • dc.contributor.author Mora, Lorena de la
  • dc.contributor.author Knobel Freud, Hernando
  • dc.contributor.author Orti, Amat
  • dc.contributor.author Martín-Iguacel, Raquel
  • dc.contributor.author Miró, José María
  • dc.contributor.author Casabona, Jordi
  • dc.contributor.author Reyes-Urueña, Juliana
  • dc.date.accessioned 2025-07-11T07:01:25Z
  • dc.date.available 2025-07-11T07:01:25Z
  • dc.date.issued 2024
  • dc.description.abstract Background: Effective antiretroviral therapy (ART) has substantially reduced acquired immunodeficiency syndrome (AIDS)-related deaths, shifting the focus to non-AIDS conditions in people living with human immunodeficiency virus (HIV) (PLWH). We examined mortality trends and predictors of AIDS- and non-AIDS mortality in the Population HIV Cohort from Catalonia and Balearic Islands (PISCIS) cohort of PLWH from 1998 to 2020. Methods: We used a modified Coding Causes of Death in HIV protocol, which has been widely adopted by various HIV cohorts to classify mortality causes. We applied standardized mortality rates (SMR) to compare with the general population and used competing risks models to determine AIDS-related and non-AIDS-related mortality predictors. Results: Among 30 394 PLWH (81.5% male, median age at death 47.3), crude mortality was 14.2 per 1000 person-years. All-cause standardized mortality rates dropped from 9.6 (95% confidence interval [CI], 8.45-10.90) in 1998 through 2003 to 3.33 (95% CI, 3.14-3.53) in 2015 through 2020, P for trend = .0001. Major causes were AIDS, non-AIDS cancers, cardiovascular disease, AIDS-defining cancers, viral hepatitis, and nonhepatitis liver disease. Predictors for AIDS-related mortality included being aged ≥40 years, not being a man who have sex with men, history of AIDS-defining illnesses, CD4 < 200 cells/µL, ≥2 comorbidities, and nonreceipt of ART. Non-AIDS mortality increased with age, injection drug use, heterosexual men, socioeconomic deprivation, CD4 200 to 349 cells/µL, nonreceipt of ART, and comorbidities, but migrants had lower risk (adjusted hazard risk, 0.69 [95% CI, .57-.83]). Conclusions: Mortality rates among PLWH have significantly decreased over the past 2 decades, with a notable shift toward non-AIDS-related causes. Continuous monitoring and effective management of these non-AIDS conditions are essential to enhance overall health outcomes.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Nomah DK, Jamarkattel S, Bruguera A, Moreno-Fornés S, Díaz Y, Alonso L, et al. Evolving AIDS- and non-AIDS mortality and predictors in the PISCIS cohort of people living with HIV in Catalonia and the Balearic Islands (Spain), 1998-2020. Open Forum Infect Dis. 2024 Mar 8;11(4):ofae132. DOI: 10.1093/ofid/ofae132
  • dc.identifier.doi http://dx.doi.org/10.1093/ofid/ofae132
  • dc.identifier.issn 2328-8957
  • dc.identifier.uri http://hdl.handle.net/10230/70890
  • dc.language.iso eng
  • dc.publisher Oxford University Press
  • dc.relation.ispartof Open Forum Infect Dis. 2024 Mar 8;11(4):ofae132
  • dc.rights © The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword AIDS
  • dc.subject.keyword HIV
  • dc.subject.keyword Antiretroviral therapy
  • dc.subject.keyword Mortality
  • dc.subject.keyword Non-AIDS cancers
  • dc.title Evolving AIDS- and non-AIDS mortality and predictors in the PISCIS cohort of people living with HIV in Catalonia and the Balearic Islands (Spain), 1998-2020
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Hospital del Mar Research Institute)