Functional structure of local connections and differentiation of cerebral cortex areas in the neonate

Pujol, Jesús; Blanco Hinojo, Laura, 1981-; Persavento, Cecilia; Martínez-Vilavella, Gerard; Falcón, Carles; Gascon Merlos, Mireia, 1984-; Rivas, Ioar; Vilanova, Marc; Deus, Joan; Gispert López, Juan Domingo; Gómez-Roig, María Dolores; Llurba, Elisa; Dadvand, Payam; Sunyer Deu, Jordi

Functional structure of local connections and differentiation of cerebral cortex areas in the neonate

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dc.contributor.author Pujol, Jesús
dc.contributor.author Blanco Hinojo, Laura, 1981-
dc.contributor.author Persavento, Cecilia
dc.contributor.author Martínez-Vilavella, Gerard
dc.contributor.author Falcón, Carles
dc.contributor.author Gascon Merlos, Mireia, 1984-
dc.contributor.author Rivas, Ioar
dc.contributor.author Vilanova, Marc
dc.contributor.author Deus, Joan
dc.contributor.author Gispert López, Juan Domingo
dc.contributor.author Gómez-Roig, María Dolores
dc.contributor.author Llurba, Elisa
dc.contributor.author Dadvand, Payam
dc.contributor.author Sunyer Deu, Jordi
dc.date.accessioned 2024-11-21T07:41:28Z
dc.date.available 2024-11-21T07:41:28Z
dc.date.issued 2024
dc.description.abstract Neuroimaging research on functional connectivity can provide valuable information on the developmental differentiation of the infant cerebral cortex into its functional areas. We examined healthy neonates to comprehensively map brain functional connectivity using a combination of local measures that uniquely capture the rich spatial structure of cerebral cortex functional connections. Optimal functional MRI scans were obtained in 61 neonates. Local functional connectivity maps were based on Iso-Distance Average Correlation (IDAC) measures. Single distance maps and maps combining three distinct IDAC measures were used to assess different levels of cortical area functional differentiation. A set of brain areas showed higher connectivity than the rest of the brain parenchyma in each local distance map. These areas were consistent with those supporting basic aspects of the neonatal repertoire of adaptive behaviors and included the sensorimotor, auditory and visual cortices, the frontal operculum/anterior insula (relevant for sucking, swallowing and the sense of taste), paracentral lobule (processing anal and urethral sphincter activity), default mode network (relevant for self-awareness), and limbic-emotional structures such as the anterior cingulate cortex, amygdala and hippocampus. However, the results also indicate that brain areas presumed to be actively developing may not necessarily be mature. In fact, combined distance, second-level maps confirmed that the functional differentiation of the cerebral cortex into functional areas in neonates is far from complete. Our results provide a more comprehensive understanding of the developing brain systems, while also highlighting the substantial developmental journey that the neonatal brain must undergo to reach adulthood.
dc.description.sponsorship We would like to thank all the participants and their families for their generous collaboration. The overall study cohort (mother-child Barcelona Life Study Cohort- BiSC) has received additional funding from the Health Effects Institute (4959-RFA17–1/18–1 – FRONTIER project), from the European Union's Horizon 2020 research and innovation programme-EU.3.1.2. (874583 - ATHLETE project) and H2020-EU.3.1.1 (GA964827 – AURORA project), from ANSES (2019/01/039 - HyPAXE project), from the AGAUR-Agència de Gestió d'Ajuts Universitaris de Recerca (2017 SGR 826 and 2021 SGR 00717), from the CIBERESP Epidemiología y salud pública (CB06/02/0041), from RICORS funded by the Recovery, Transformation and Resilience Plan 2017–2020, ISCIII, and Maternal and Child Health and Development Network (SAMID) RD16/0022/0015 and RD16/0022/0015, Instituto de Salud Carlos III and by the European Union – Next Generation EU, ref RD21/0012/0001 and RD21/0012/0003. Mireia Gascon acknowledges funding from Miguel Servet fellowship (Grant CP19/00183) and Ioar Rivas from Marie Skłodowska-Curie grant (agreement No 886121). A full list of BiSC researchers can be found at https://projectebisc.org/en/team/.
dc.format.mimetype application/pdf
dc.identifier.citation Pujol J, Blanco-Hinojo L, Persavento C, Martínez-Vilavella G, Falcón C, Gascón M, et al. Functional structure of local connections and differentiation of cerebral cortex areas in the neonate. Neuroimage. 2024 Sep;298:120780. DOI: 10.1016/j.neuroimage.2024.120780
dc.identifier.doi http://dx.doi.org/10.1016/j.neuroimage.2024.120780
dc.identifier.issn 1053-8119
dc.identifier.uri http://hdl.handle.net/10230/68760
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Neuroimage. 2024 Sep;298:120780
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/886121
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Development
dc.subject.keyword Functional connectivity
dc.subject.keyword MRI
dc.subject.keyword Neonates, cortical areas
dc.title Functional structure of local connections and differentiation of cerebral cortex areas in the neonate
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
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Documents OpenAIRE (Open Access Infrastructure for Research in Europe)