A model of drosophila larva chemotaxis
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- dc.contributor.author Davies, Alex
- dc.contributor.author Louis, Matthieu
- dc.contributor.author Webb, Barbara
- dc.date.accessioned 2023-12-12T06:36:36Z
- dc.date.available 2023-12-12T06:36:36Z
- dc.date.issued 2015
- dc.description.abstract Detailed observations of larval Drosophila chemotaxis have characterised the relationship between the odour gradient and the runs, head casts and turns made by the animal. We use a computational model to test whether hypothesised sensorimotor control mechanisms are sufficient to account for larval behaviour. The model combines three mechanisms based on simple transformations of the recent history of odour intensity at the head location. The first is an increased probability of terminating runs in response to gradually decreasing concentration, the second an increased probability of terminating head casts in response to rapidly increasing concentration, and the third a biasing of run directions up concentration gradients through modulation of small head casts. We show that this model can be tuned to produce behavioural statistics comparable to those reported for the larva, and that this tuning results in similar chemotaxis performance to the larva. We demonstrate that each mechanism can enable odour approach but the combination of mechanisms is most effective, and investigate how these low-level control mechanisms relate to behavioural measures such as the preference indices used to investigate larval learning behaviour in group assays
- dc.description.sponsorship This work was funded by: Grants EP/F500385/1 and BB/F529254/1 for the University of Edinburgh School of Informatics Doctoral Training Centre in Neuroinformatics and Computational Neuroscience (http://www.anc.ed.ac.uk/dtc/) from the UK Engineering and Physical Sciences Research Council (www.epsrc.ac.uk), UK Biotechnology and Biological Sciences Research Council (http://www.bbsrc.ac.uk/) and the UK Medical Research Council (http://www.mrc.ac.uk) to AD; Project MINIMAL (618045) grant from the EU’s Seventh Framework Programme for Research (ec.europa.eu/research/fp7) to BW, ML; and Grant BFU2011-483 26208 from the Spanish Ministry of Science and Innovation (www.micinn.es), and the European Molecular Biology Laboratory/ Centre for Genomic Regulation Systems Biology Program to ML. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
- dc.format.mimetype application/pdf
- dc.identifier.citation Davies A, Louis M, Webb B. A model of drosophila larva chemotaxis. PLoS Comput Biol. 2015 Nov 24;11(11):e1004606. DOI: 10.1371/journal.pcbi.1004606
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pcbi.1004606
- dc.identifier.issn 1553-7358
- dc.identifier.uri http://hdl.handle.net/10230/58496
- dc.language.iso eng
- dc.publisher Public Library of Science (PLoS)
- dc.relation.ispartof PLoS Computational Biology. 2015 Nov 24;11(11):e1004606
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/618045
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-26208
- dc.rights © 2015 Davies et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.other Quimiotaxi
- dc.subject.other Larves
- dc.subject.other Locomoció animal
- dc.title A model of drosophila larva chemotaxis
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion