Radiofrequency echographic multi spectrometry (REMS) for the diagnosis of osteoporosis in a European multicenter clinical context

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• dc.contributor.author Cortet, Bernard
• dc.contributor.author Dennison, Elaine
• dc.contributor.author Diez-Perez, Adolfo
• dc.contributor.author Locquet, Médéa
• dc.contributor.author Muratore, Maurizio
• dc.contributor.author Nogués Solan, Francesc Xavier
• dc.contributor.author Ovejero Crespo, Diana
• dc.contributor.author Quarta, Eugenio
• dc.contributor.author Brandi, María Luisa
• dc.date.accessioned 2021-06-02T07:31:38Z
• dc.date.available 2021-06-02T07:31:38Z
• dc.date.issued 2021
• dc.description.abstract Background: Radiofrequency Echographic Multi Spectrometry (REMS) is a non-ionizing technology for the densitometric assessment of osteoporosis. It has already been validated in Italian women with respect to the current clinical reference technology, Dual-energy X-ray Absorptiometry (DXA). Purpose: Aim of the current study was to assess the diagnostic accuracy of REMS technology with respect to DXA in a wider European clinical context. Methods: A total of 4307 female Caucasian patients aged between 30 and 90 years underwent DXA and REMS scans at femoral neck and/or lumbar spine (the site depending on the medical prescription). The acquired data underwent a rigorous quality check in order to exclude the erroneous DXA and REMS reports. The diagnostic agreement between the two technologies was assessed, also stratifying for patients' age groups. The ability to recognise previously fractured patients was also investigated. Results: Overall, 4245 lumbar spine scans and 4271 femoral neck scans were performed. The ability to discriminate patients with and without osteoporosis by femoral neck investigation resulted in sensitivity and specificity of 90.4% and 95.5%, respectively. For lumbar spine scans, a sensitivity of 90.9% and a specificity of 95.1% were obtained. The areas under the curve (AUCs) of the Receiver Operating Characteristic (ROC) curve evaluating the ability to discriminate groups of patients with previous osteoporotic fracture using DXA and REMS T-score values were 0.631 and 0.683 (p < 0.0001), respectively, for femoral neck scans, whereas 0.603 and 0.640 (p = 0.0002), respectively, for lumbar spine scans. Conclusion: The diagnostic effectiveness of REMS technology at reference anatomical sites for the assessment of osteoporosis has been confirmed in a large series of female patients, spanning from younger and pre-menopausal to elderly women up to 90 years, in a multicenter European clinical context.
• dc.format.mimetype application/pdf
• dc.identifier.citation Cortet B, Dennison E, Diez-Perez A, Locquet M, Muratore M, Nogués X, et al. Radiofrequency echographic multi spectrometry (REMS) for the diagnosis of osteoporosis in a European multicenter clinical context. Bone. 2021 Feb; 143: 115786. DOI: 10.1016/j.bone.2020.115786
• dc.identifier.doi http://dx.doi.org/10.1016/j.bone.2020.115786
• dc.identifier.issn 1873-2763
• dc.identifier.uri http://hdl.handle.net/10230/47714
• dc.language.iso eng
• dc.publisher Elsevier
• dc.rights 8756-3282/© 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY licensce (http://creativecommons.org/licenses/by/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Dual-energy X-ray Absorptiometry (DXA)
• dc.subject.keyword European multicentre study
• dc.subject.keyword Femoral neck
• dc.subject.keyword Lumbar spine
• dc.subject.keyword Osteoporosis diagnosis
• dc.subject.keyword Radiofrequency Echographic Multi Spectrometry (REMS)
• dc.title Radiofrequency echographic multi spectrometry (REMS) for the diagnosis of osteoporosis in a European multicenter clinical context
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion