Psychotic experiences and general medical conditions: a cross-national analysis based on 28 002 respondents from 16 countries in the WHO World Mental Health Surveys

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• dc.contributor.author Scott, Kate M.
• dc.contributor.author Alonso Caballero, Jordi
• dc.contributor.author McGrath, John J.
• dc.date.accessioned 2019-05-09T07:12:19Z
• dc.date.available 2019-05-09T07:12:19Z
• dc.date.issued 2018
• dc.description.abstract Background: Previous work has identified associations between psychotic experiences (PEs) and general medical conditions (GMCs), but their temporal direction remains unclear as does the extent to which they are independent of comorbid mental disorders. Methods: In total, 28 002 adults in 16 countries from the WHO World Mental Health (WMH) Surveys were assessed for PEs, GMCs and 21 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) mental disorders. Discrete-time survival analyses were used to estimate the associations between PEs and GMCs with various adjustments. Results: After adjustment for comorbid mental disorders, temporally prior PEs were significantly associated with subsequent onset of 8/12 GMCs (arthritis, back or neck pain, frequent or severe headache, other chronic pain, heart disease, high blood pressure, diabetes and peptic ulcer) with odds ratios (ORs) ranging from 1.3 [95% confidence interval (CI) 1.1–1.5] to 1.9 (95% CI 1.4–2.4). In contrast, only three GMCs (frequent or severe headache, other chronic pain and asthma) were significantly associated with subsequent onset of PEs after adjustment for comorbid GMCs and mental disorders, with ORs ranging from 1.5 (95% CI 1.2–1.9) to 1.7 (95% CI 1.2–2.4). Conclusions: PEs were associated with the subsequent onset of a wide range of GMCs, independent of comorbid mental disorders. There were also associations between some medical conditions (particularly those involving chronic pain) and subsequent PEs. Although these findings will need to be confirmed in prospective studies, clinicians should be aware that psychotic symptoms may be risk markers for a wide range of adverse health outcomes. Whether PEs are causal risk factors will require further research.
• dc.description.sponsorship The ESEMeD surveys were funded by the European Commission (Contracts QLG5‐1999‐01042; SANCO 2004123, and EAHC 20081308), the Piedmont Region (Italy)), Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Spain (FIS 00/0028), Ministerio de Ciencia y Tecnología, Spain (SAF 2000‐158‐CE), Departament de Salut, Generalitat de Catalunya, Spain, Instituto de Salud Carlos III (CIBER CB06/02/0046, RETICS RD06/0011 REM‐TAP), and other local agencies and by an unrestricted educational grant from GlaxoSmithKline.
• dc.format.mimetype application/pdf
• dc.identifier.citation Scott KM, Saha S, Lim CCW, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J et al. Psychotic experiences and general medical conditions: a cross-national analysis based on 28 002 respondents from 16 countries in the WHO World Mental Health Surveys. Psychol Med. 2018; 48(16):2730-2739. DOI 10.1017/S0033291718000363
• dc.identifier.doi http://dx.doi.org/10.1017/S0033291718000363
• dc.identifier.issn 0033-2917
• dc.identifier.uri http://hdl.handle.net/10230/37195
• dc.language.iso eng
• dc.publisher Cambridge University Press
• dc.relation.ispartof Psychol Med. 2018; 48(16):2730-2739
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PN/SAF2000-158-CE
• dc.rights © Cambridge University Press. The published version of the article: Scott KM, Saha S, Lim CCW, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J et al. Psychotic experiences and general medical conditions: a cross-national analysis based on 28 002 respondents from 16 countries in the WHO World Mental Health Surveys. Psychol Med. 2018; 48(16):2730-2739. DOI 10.1017/S0033291718000363 is available at https://www.cambridge.org/core/journals/psychological-medicine.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Arthritis
• dc.subject.keyword Asthma
• dc.subject.keyword Diabetes
• dc.subject.keyword General medical conditions
• dc.subject.keyword Headache
• dc.subject.keyword Heart disease
• dc.subject.keyword Mental disorders
• dc.subject.keyword Pain
• dc.subject.keyword Physical disorders
• dc.subject.keyword Psychotic experiences
• dc.title Psychotic experiences and general medical conditions: a cross-national analysis based on 28 002 respondents from 16 countries in the WHO World Mental Health Surveys
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion