Shaping the transcriptional landscape through MAPK signaling

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• dc.contributor.author Nadal Ribelles, Mariona, 1984-
• dc.contributor.author Solé Serra, Carme
• dc.contributor.author Martínez Cebrián, Gerard, 1992-
• dc.contributor.author Posas Garriga, Francesc
• dc.contributor.author Nadal Clanchet, Eulàlia de
• dc.date.accessioned 2025-05-26T07:05:27Z
• dc.date.available 2025-05-26T07:05:27Z
• dc.date.issued 2019
• dc.description.abstract A change in the transcriptional landscape is an equilibrium-breaking event important for many biological processes. Mitogen-activated protein kinase (MAPK) signaling pathways are dedicated to sensing extracellular cues and are highly conserved across eukaryotes. Modulation of gene expression in response to the extracellular environment is one of the main mechanisms by which MAPK regulates proteome homeostasis to orchestrate adaptive responses that determine cell fate. A massive body of knowledge generated from population and single-cell analyses has led to an understanding of how MAPK pathways operate. MAPKs have thus emerged as fundamental transcriptome regulators that function through a multi-layered control of gene expression, a process often deregulated in disease, which therefore provides an attractive target for therapeutic strategies. Here, we summarize the current understanding of the mechanisms underlying MAPK-mediated gene expression in organisms ranging from yeast to mammals.en
• dc.description.sponsorship MNR is a recipient of a Maria de Maeztu Postdoctoral Fellowship (Doctores Banco de Santander-María de Maeztu at Universitat Pompeu Fabra). GMC is a recipient of an FPI Predoctoral Fellowship (Spanish Ministry of Economy and Industry and Competitiveness (MINECO). The FP and EdN’s laboratory is supported by grants from the Spanish Ministry of Economy and Competitiveness (BFU2015-64437-P to FP and BFU2017-85152-P and FEDER to EN), the Catalan Government (2017 SGR 799), the Fundación Botín, and the Banco Santander through its Santander Universities Global Division to FP and the Unidad de Excelencia Maria de Maeztu, MDM-2014-0370. FP is a recipient of an ICREA Acadèmia (Generalitat de Catalunya). We gratefully acknowledge funding from the Spanish Ministry of Economy, Industry, and Competitiveness (MINECO) through the Centers of Excellence Severo Ochoa award and from the CERCA Program of the Catalan Government.en
• dc.format.mimetype application/pdf
• dc.identifier.citation Nadal-Ribelles M, Solé C, Martínez-Cebrián G, Posas F, de Nadal E. Shaping the transcriptional landscape through MAPK signaling. In: Uchiumi F, editor. Gene expression and control. London, United Kingdom: Intechopen; 2019. p. 1-22. DOI: 10.5772/intechopen.80634
• dc.identifier.doi http://dx.doi.org/10.5772/intechopen.80634
• dc.identifier.isbn 9781789855173
• dc.identifier.uri http://hdl.handle.net/10230/70487
• dc.language.iso eng
• dc.publisher IntechOpen
• dc.relation.ispartof Uchiumi F, editor. Gene expression and control. London, United Kingdom: Intechopen; 2019. p. 1-22
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-64437-P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2017-85152-P
• dc.rights © 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/3.0/
• dc.subject.keyword MAP kinasesen
• dc.subject.keyword Signal transductionen
• dc.subject.keyword Transcriptionen
• dc.subject.keyword Gene expressionen
• dc.subject.keyword Chromatinen
• dc.title Shaping the transcriptional landscape through MAPK signalingen
• dc.type info:eu-repo/semantics/bookPart
• dc.type.version info:eu-repo/semantics/publishedVersion