Spatial dynamics of synthetic microbial mutualists and their parasites

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• dc.contributor.author Amor, Daniel R.ca
• dc.contributor.author Montañez, Raúlca
• dc.contributor.author Duran Nebreda, Salvador, 1987-ca
• dc.contributor.author Solé Vicente, Ricard, 1962-ca
• dc.date.accessioned 2018-01-23T13:08:39Z
• dc.date.available 2018-01-23T13:08:39Z
• dc.date.issued 2017
• dc.description.abstract A major force contributing to the emergence of novelty in nature is the presence of cooperative interactions, where two or more components of a system act in synergy, sometimes leading to higher-order, emergent phenomena. Within molecular evolution, the so called hypercycle defines the simplest model of an autocatalytic cycle, providing major theoretical insights on the evolution of cooperation in the early biosphere. These closed cooperative loops have also inspired our understanding of how catalytic loops appear in ecological systems. In both cases, hypercycle and ecological cooperative loops, the role played by space seems to be crucial for their stability and resilience against parasites. However, it is difficult to test these ideas in natural ecosystems, where time and spatial scales introduce considerable limitations. Here, we use engineered bacteria as a model system to a variety of environmental scenarios identifying trends that transcend the specific model system, such an enhanced genetic diversity in environments requiring mutualistic interactions. Interestingly, we show that improved environments can slow down mutualistic range expansions as a result of genetic drift effects preceding local resource depletion. Moreover, we show that a parasitic strain is excluded from the population during range expansions (which acknowledges a classical prediction). Nevertheless, environmental deterioration can reshape population interactions, this same strain becoming part of a three-species mutualistic web in scenarios in which the two-strain mutualism becomes non functional. The evolutionary and ecological implications for the design of synthetic ecosystems are outlined.
• dc.description.sponsorship This study was supported by an European Research Council Advanced Grant (SYNCOM, grant number 294294), a MINECO grant FIS2015-67616-P, by Banco Santander through its Santander Universities Global Division, the Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement de la Generalitat de Catalunya and by the Santa Fe Institute.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Amor DR, Montañez R, Duran-Nebreda S, Solé R. Spatial dynamics of synthetic microbial mutualists and their parasites. PLoS Comput Biol. 2017 Aug 21;13(8):e1005689. DOI: 10.1371/journal.pcbi.1005689
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pcbi.1005689
• dc.identifier.issn 1553-734X
• dc.identifier.uri http://hdl.handle.net/10230/33733
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)ca
• dc.relation.ispartof PLOS Computational Biology. 2017 Aug 21;13(8):e1005689
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/294294
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/FIS2015-67616-P
• dc.rights © 2017 Amor et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Microbial ecology
• dc.subject.keyword Microbial evolution
• dc.subject.keyword Parasite evolution
• dc.subject.keyword Soil ecology
• dc.subject.keyword Gut metagenome
• dc.title Spatial dynamics of synthetic microbial mutualists and their parasitesca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion