Hydrotalcite-embedded magnetite nanoparticles for hyperthermia-triggered chemotherapy

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• dc.contributor.author Simeonidis, Konstantinos
• dc.contributor.author Kaprara, Efthimia
• dc.contributor.author Rivera Gil, Pilar, 1976-
• dc.contributor.author Xu, Ruixue
• dc.contributor.author Teran, Francisco J.
• dc.contributor.author Kokkinos, Evgenios
• dc.contributor.author Mitropoulos, Athanassios
• dc.contributor.author Maniotis, Nikolaos
• dc.contributor.author Balcells, Lluis
• dc.date.accessioned 2021-08-26T06:54:12Z
• dc.date.available 2021-08-26T06:54:12Z
• dc.date.issued 2021
• dc.description.abstract A magnetic nanocomposite, consisting of Fe3O4 nanoparticles embedded into a Mg/Al layered double hydroxide (LDH) matrix, was developed for cancer multimodal therapy, based on the combination of local magnetic hyperthermia and thermally induced drug delivery. The synthesis procedure involves the sequential hydrolysis of iron salts (Fe2+, Fe3+) and Mg2+/Al3+ nitrates in a carbonate-rich mild alkaline environment followed by the loading of 5-fluorouracil, an anionic anticancer drug, in the interlayer LDH space. Magnetite nanoparticles with a diameter around 30 nm, dispersed in water, constitute the hyperthermia-active phase able to generate a specific loss of power of around 500 W/g-Fe in an alternating current (AC) magnetic field of 24 kA/m and 300 kHz as determined by AC magnetometry and calorimetric measurements. Heat transfer was found to trigger a very rapid release of drug which reached 80% of the loaded mass within 10 min exposure to the applied field. The potential of the Fe3O4/LDH nanocomposites as cancer treatment agents with minimum side-effects, owing to the exclusive presence of inorganic phases, was validated by cell internalization and toxicity assays.
• dc.description.sponsorship The project was financially supported by Stavros Niarchos Foundation and Eastern Macedonia and Thrace Institute of Technology fellowships for assisting young scientists in prototyping innovative products by using cutting-edge technology. Specific measurements received funding from the EU-H2020 research and innovation programme under grant agreement No. 654360 having benefitted from the access provided by ICMAB-CSIC and Universitat Autonoma de Barcelona in Bellaterra-Barcelona within the framework of the NFFA-Europe Transnational Access Activity. Authors would like to thank Anna Esther Carrillo for the experimental assistance during SEM observations and Bernat Bozzo for the support in SQUID measurements. This work was partially funded by Spanish Ministry of Science, Innovation and Universities (MAT2017-85617-R, SEV-2016-0686, RED2018-102626-T) and Comunidad de Madrid (NANOMAGCOST). COST Actions CA17115 (MyWave), and CA17140 (Nano2Clinic) are also acknowledged. The UPF acknowledges the Ministry of Science, Innovation and Universities (MICINN) and the AEI (RYC-2012-10059, MDM-2014-0370-04, CTQ2013-45433-PFEDER], MAT2016-75362-C3-2-R, AEI-SAF2015-73052-EXP) and the AGAUR (2017 SGR 1054) for financial support.
• dc.format.mimetype application/pdf
• dc.identifier.citation Simeonidis K, Kaprara E, Rivera-Gil P, Xu R, Teran FJ, Kokkinos E, Mitropoulos A, Maniotis N, Balcells L. Hydrotalcite-embedded magnetite nanoparticles for hyperthermia-triggered chemotherapy. Nanomaterials (Basel). 2021;11(7):1796. DOI: 10.3390/nano11071796
• dc.identifier.doi http://dx.doi.org/10.3390/nano11071796
• dc.identifier.issn 2079-4991
• dc.identifier.uri http://hdl.handle.net/10230/48331
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Nanomaterials (Basel). 2021;11(7):1796
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/654360
• dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Fe3O4
• dc.subject.keyword Cell internalization
• dc.subject.keyword Continuous flow synthesis
• dc.subject.keyword Drug delivery
• dc.subject.keyword Layered double hydroxide
• dc.subject.keyword Magnetic hyperthermia
• dc.subject.keyword Nanocomposite
• dc.title Hydrotalcite-embedded magnetite nanoparticles for hyperthermia-triggered chemotherapy
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion