Identification and characterization of novel bat coronaviruses in Spain

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• dc.contributor.author Soriano-Tordera, Clàudia
• dc.contributor.author Buigues, Jaime
• dc.contributor.author Viñals, Adrià
• dc.contributor.author Muscolino, Elena
• dc.contributor.author Martínez-Recio, Raquel
• dc.contributor.author Díez Antón, Juana, 1962-
• dc.contributor.author Monrós, Juan S.
• dc.contributor.author Cuevas, José M.
• dc.contributor.author Dufloo, Jérémy
• dc.contributor.author Sanjuán, Rafael
• dc.date.accessioned 2025-11-07T14:59:43Z
• dc.date.available 2025-11-07T14:59:43Z
• dc.date.issued 2025
• dc.date.updated 2025-11-07T14:59:43Z
• dc.description.abstract The zoonotic transmission of bat coronaviruses poses a threat to human health. However, the diversity of bat-borne coronaviruses remains poorly characterized in many geographical areas. Here, we recovered eight coronavirus genomes by performing a metagenomic analysis of fecal samples from hundreds of individual bats captured in Spain, a country with high bat diversity. Three of these genomes corresponded to potentially novel coronavirus species belonging to the alphacoronavirus genus. Phylogenetic analyses revealed that some of these viruses are closely related to coronaviruses previously described in bats from other countries, suggesting a shared viral reservoir worldwide. Using viral pseudotypes, we investigated the receptor usage of the identified viruses and found that one of them can use human ACE2, albeit with lower affinity than SARS-CoV-2. However, the receptor usage of the other viruses remains unknown. This study broadens our understanding of coronavirus diversity and identifies research priorities for the prevention of zoonotic viral outbreaks.
• dc.description.sponsorship This research was financially supported the European Research Council (ERC; Advanced Grant (101019724-EVADER to R.S.), the Spanish Ministerio de Ciencia e Innovación (MICINN; grant PID2020-118602RB-I00 to R.S. and J.M.C.), the Conselleria de Educación, Universidades y Empleo (Generalitat Valenciana; grant CIAICO/2022/110 to R.S.), the European Molecular Biology Organization (EMBO; postdoctoral fellowship ALTF 140-2021 to J.Du. and R.S.), and the Sklodowska-Curie Actions (postdoctoral fellowship 101104880 to J.Du. and R.S.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
• dc.format.mimetype application/pdf
• dc.identifier.citation Soriano-Tordera C, Buigues J, Viñals A, Muscolino E, Martinez-Recio R, Diez J, Monros JS, Cuevas JM, Dufloo J, Sanjuan R. Identification and characterization of novel bat coronaviruses in Spain. PLoS Pathog. 2025 Aug 4;21(8):e1013371. DOI: 10.1371/journal.ppat.1013371
• dc.identifier.doi http://dx.doi.org/10.1371/journal.ppat.1013371
• dc.identifier.issn 1553-7366
• dc.identifier.uri http://hdl.handle.net/10230/71811
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)
• dc.relation.ispartof PLOS Pathogens. 2025;21(8):e1013371
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101019724
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-118602RB-I00
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101104880
• dc.rights © 2025 Soriano-Tordera et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Coronaviruses
• dc.subject.keyword Bats
• dc.subject.keyword COVID 19
• dc.subject.keyword Genomics
• dc.subject.keyword SARS CoV 2
• dc.subject.keyword Phylogenetic analysis
• dc.subject.keyword Polymerase chain reaction
• dc.subject.keyword RNA extraction
• dc.title Identification and characterization of novel bat coronaviruses in Spain
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion