Sustained low disease activity measured by ASDAS slow radiographic spinal progression in axial spondyloarthritis patients treated with TNF-inhibitors: data from REGISPONSERBIO

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• dc.contributor.author Llop, Maria
• dc.contributor.author Moreno, Mireia
• dc.contributor.author Navarro-Compán, Victoria
• dc.contributor.author Juanola, Xavier
• dc.contributor.author Miguel, Eugenio de
• dc.contributor.author Almodóvar, Raquel
• dc.contributor.author Cuende Quintana, Eduardo
• dc.contributor.author Sanz Sanz, Jesús
• dc.contributor.author Beltrán, Emma
• dc.contributor.author Ruiz Montesinos, M. Dolores
• dc.contributor.author Calvet, Joan
• dc.contributor.author Berenguer-Llergo, Antonio
• dc.contributor.author Gratacós, Jordi
• dc.contributor.author Regisponserbio group
• dc.date.accessioned 2022-07-27T13:56:58Z
• dc.date.available 2022-07-27T13:56:58Z
• dc.date.issued 2022
• dc.description.abstract Background: To evaluate the influence of the disease activity on radiographic progression in axial spondyloarthritis (axSpA) patients treated with TNF inhibitors (TNFi). Methods: The study included 101 axSpA patients from the Spanish Register of Biological Therapy in Spondyloarthritides (REGISPONSERBIO), which had clinical data and radiographic assessment available. Patients were classified into 2 groups based on the duration of TNFi treatment at baseline: (i) long-term treatment (≥4 years) and (ii) no long-term treatment (< 4 years). Radiographs were scored by two readers according to the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) with known chronology. Disease activity differences between patients' groups at each time point were assessed using a linear mixed-effect model. Results: Radiographic progression was defined as an increase in ≥2 mSASSS units. At inclusion, approximately half of the patients (45.5%) were receiving long-term treatment with TNFi (≥4 years). In this group of subjects, a significant difference in averaged Ankylosing Spondylitis disease Activity Score (ASDAS) across follow-up was found between progressors and non-progressors (2.33 vs 1.76, p=0.027, respectively). In patients not under long-term TNFi treatment (54.5%) though, no significant ASDAS differences were observed between progressors and non-progressors until the third year of follow-up. Furthermore, no significant differences were found in progression status, when disease activity was measured by Bath Ankylosing spondylitis Disease Activity Index (BASDAI) and C reactive protein (CRP). Conclusions: Patients on long-term TNFi treatment with a mean sustained low disease activity measures by ASDAS presented lower radiographic progression than those with active disease.
• dc.format.mimetype application/pdf
• dc.identifier.citation Llop M, Moreno M, Navarro-Compán V, Juanola X, de Miguel E, Almodóvar R, Quintana EC, Sanz JS, Beltrán E, Montesinos MDR, Calvet J, Berenguer-Llergo A, Gratacós J; Regisponserbio group. Sustained low disease activity measured by ASDAS slow radiographic spinal progression in axial spondyloarthritis patients treated with TNF-inhibitors: data from REGISPONSERBIO. Arthritis Res Ther. 2022 Jan 21;24(1):30. DOI: 10.1186/s13075-021-02695-5
• dc.identifier.doi http://dx.doi.org/10.1186/s13075-021-02695-5
• dc.identifier.issn 1478-6354
• dc.identifier.uri http://hdl.handle.net/10230/53861
• dc.language.iso eng
• dc.publisher BioMed Central
• dc.relation.ispartof Arthritis Res Ther. 2022 Jan 21;24(1):30
• dc.rights © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Biological therapies
• dc.subject.keyword Inflammation
• dc.subject.keyword Outcome measures
• dc.subject.keyword Radiology
• dc.subject.keyword Spondyloarthritis
• dc.title Sustained low disease activity measured by ASDAS slow radiographic spinal progression in axial spondyloarthritis patients treated with TNF-inhibitors: data from REGISPONSERBIO
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion