A longitudinal prospective study of active tuberculosis in a Western Europe setting: insights and findings

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  • dc.contributor.author Romero Tamarit, Arantxa
  • dc.contributor.author Munar García, María
  • dc.contributor.author Domínguez Álvarez, Marisol
  • dc.contributor.author Jové, Neus
  • dc.contributor.author Vilaplana Massaguer, Cristina
  • dc.date.accessioned 2024-10-21T06:46:30Z
  • dc.date.available 2024-10-21T06:46:30Z
  • dc.date.issued 2024
  • dc.description.abstract Purpose: This study investigates the potential of inflammatory parameters (IP), symptoms, and patient-related outcome measurements as biomarkers of severity and their ability to predict tuberculosis (TB) evolution. Methods: People with TB were included prospectively in the Stage-TB study conducted at five clinical sites in Barcelona (Spain) between April 2018 and December 2021. Data on demographics, epidemiology, clinical features, microbiology, and Sanit George Respiratory Questionnaire (SGRQ) and Kessler-10 as Health-Related Quality of Life (HRQoL) were collected at three time points during treatment. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophil/lymphocyte, and monocyte/lymphocyte ratios (NLR and MLR), complement factors C3, C4, and cH50, clinical and microbiological data, and HRQoL questionnaires were assessed at baseline, 2 months, and 6 months. Their ability to predict sputum culture conversion (SCC) and symptom presence after 2 months of treatment was also analysed. Results: The study included 81 adults and 13 children with TB. The CRP, ESR, NLR, and MLR values, as well as the presence of symptoms, decreased significantly over time in both groups. Higher IP levels at baseline were associated with greater bacillary load and persistent symptoms. Clinical severity at baseline predicted a delayed SCC. Kessler-10 improved during follow-up, but self-reported lung impairment (SGRQ) persisted in all individuals after 6 months. Conclusions: IP levels may indicate disease severity, and sustained high levels are linked to lower treatment efficacy. Baseline clinical severity is the best predictor of SCC. Implementing health strategies to evaluate lung function and mental health throughout the disease process may be crucial for individuals with TB.
  • dc.description.sponsorship This work was supported by the Catalan Government via 2017 SGR 500, 2021 SGR 00920; the Spanish Government-FEDER Funds via CPII18/00031, PI20/01424, PI22/00766, the CIBER Enfermedades Respiratorias (CB06/06/0031); and the Spanish Society of Pneumology and Thoracic Surgery, under Grant No. 169-2022. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement No. 847762.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Romero-Tamarit A, Vallès X, Munar-García M, Espinosa-Pereiro J, Saborit N, Tortola MT, et al. A longitudinal prospective study of active tuberculosis in a Western Europe setting: insights and findings. Infection. 2024 Apr;52(2):611-23. DOI: 10.1007/s15010-024-02184-2
  • dc.identifier.doi http://dx.doi.org/10.1007/s15010-024-02184-2
  • dc.identifier.issn 0300-8126
  • dc.identifier.uri http://hdl.handle.net/10230/68268
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof Infection. 2024 Apr;52(2):611-23
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/847762
  • dc.rights © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Mycobacterium tuberculosis
  • dc.subject.keyword Biomarkers
  • dc.subject.keyword Clinical monitoring
  • dc.subject.keyword HRQoL
  • dc.subject.keyword Inflammatory parameters
  • dc.title A longitudinal prospective study of active tuberculosis in a Western Europe setting: insights and findings
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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