P53 expression correlates with low axillary tumor burden in breast cancer
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- dc.contributor.author Nicolau, Pau
- dc.contributor.author Masó, Paula
- dc.contributor.author Argudo Aguirre, Nuria
- dc.contributor.author Jiménez Gómez, Marta
- dc.contributor.author Martínez, Anabel
- dc.contributor.author Vázquez, Ivonne
- dc.contributor.author Comerma Blesa, Laura, 1983-
- dc.contributor.author Vernet-Tomás, Maria
- dc.date.accessioned 2024-10-16T06:14:33Z
- dc.date.available 2024-10-16T06:14:33Z
- dc.date.issued 2023
- dc.description.abstract Background: The p53 mutation in breast cancer confers a worse prognosis and is usually associated with p53 overexpression (p53+) on immunohistochemistry. Previous studies have shown that p53+ tumors could be associated with low axillary tumor burden (ATB). Objective: We aimed to evaluate the association between p53+ and ATB in a large series of breast cancers as an aid to personalizing axillary surgical treatment. Methods: We retrieved 1762 infiltrating breast carcinomas from our database that were treated with upfront surgery in Hospital del Mar from 2004 to 2018. We compared p53+ and p53-negative (p53-) tumors in terms of the percentage of cases with high ATB and overall survival. This comparison was made overall and for each immunophenotype. Results: Overall, 18.7% of breast tumors were p53+. High ATB was less common in p53+ tumors than in p53- tumors in the luminal B-Her2-negative immunophenotype (6.2% versus 16.9%, respectively, P = 0.025), but not in the other immunophenotypes or overall. Overall survival was worse in patients with p53+ breast cancer (P = 0.002). Conclusion: p53+ breast cancers were associated with worse overall survival. However, low ATB was more common in these tumors than in p53- tumors in the luminal B-Her2-negative subtype. Information on p53 expression could be of use to predict ATB in some breast cancer tumors.
- dc.format.mimetype application/pdf
- dc.identifier.citation Nicolau P, Masó P, Argudo N, Jiménez M, Martínez AI, Vázquez I, et al. P53 expression correlates with low axillary tumor burden in breast cancer. Breast Dis. 2023;42(1):429-35. DOI: 10.3233/BD-230013
- dc.identifier.doi http://dx.doi.org/10.3233/BD-230013
- dc.identifier.issn 0888-6008
- dc.identifier.uri http://hdl.handle.net/10230/61415
- dc.language.iso eng
- dc.publisher IOS Press
- dc.relation.ispartof Breast Dis. 2023;42(1):429-35
- dc.rights The final publication is available at IOS Press through http://dx.doi.org/10.3233/BD-230013
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Axillary tumor burden
- dc.subject.keyword Breast cancer
- dc.subject.keyword Immunophenotypes
- dc.subject.keyword p53
- dc.title P53 expression correlates with low axillary tumor burden in breast cancer
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion