CLL cells cumulate genetic aberrations prior to the first therapy even in outwardly inactive disease phase

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  • dc.contributor.author Hernández-Sánchez, María
  • dc.contributor.author Kotaskova, Jana
  • dc.contributor.author Rodríguez, Ana E.
  • dc.contributor.author Radova, Lenka
  • dc.contributor.author Tamborero Noguera, David
  • dc.contributor.author Abáigar, María
  • dc.contributor.author Plevova, Karla
  • dc.contributor.author Benito, Rocío
  • dc.contributor.author Tom, Nikola
  • dc.contributor.author Quijada-Álamo, Miguel
  • dc.contributor.author Bikos, Vasileos
  • dc.contributor.author Martín, Ana África
  • dc.contributor.author Pal, Karol
  • dc.contributor.author García de Coca, Alfonso
  • dc.contributor.author Doubek, Michael
  • dc.contributor.author López Bigas, Núria
  • dc.contributor.author Hernández-Rivas, Jesús María
  • dc.contributor.author Pospisilova, Sarka
  • dc.date.accessioned 2019-06-11T07:31:25Z
  • dc.date.available 2019-06-11T07:31:25Z
  • dc.date.issued 2019
  • dc.description.sponsorship The research leading to these results has mainly received funding from the European Union Seventh Framework Programme [FP7/2007–2013] under Grant Agreement no 306242-NGS-PTL. In addition, this work was supported by grants from the Spanish Fondo de Investigaciones Sanitarias PI15/01471, PI18/01500, Instituto de Salud Carlos III (ISCIII), European Regional Development Fund (ERDF) “Una manera de hacer Europa”, “Consejería de Educación, Junta de Castilla y León” (SA085U16), “Proyectos de Investigación del SACYL”, Spain: GRS 994/A/14, BIO/SA10/14, BIO/SA31/13, GRS 1172/A/15,“Fundación Memoria Don Samuel Solórzano Barruso”, by grants (RD12/0036/0069) from Red Temática de Investigación Cooperativa en Cáncer (RTICC), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) CB16/12/00233 and USAL "Programa XIII". M. Hernández-Sánchez is supported by FEHH-Janssen (“Sociedad Española de Hematología y Hemoterapia”). M Quijada-Álamo is supported by an “Ayuda Predoctoral de la Junta de Castilla y León” (JCYL-EDU/529/2017). We are grateful to I. Rodríguez, S. González, T.Prieto, M. Á. Ramos, A. Martín, A. Díaz, A. Simón, M.del Pozo, V. Gutiérrez and S. Pujante from Centro de Investigación del Cáncer, Salamanca, for their technical assistance. D. Tamborero is supported by project SAF2015–74072-JUN, which is funded by the Agencia Estatal de Investigación (AEI) and Fondo Europeo de Dearrollo Regional (FEDER). This work was supported by Seventh Framework Programme (NGS-PTL/2012–2015/no.306242) and Ministry of Education, Youth and Sports (2013–2015, no. 7E13008); by the Ministry of Education, Youth and Sports of the Czech Republic under the CEITEC 2020 project (LQ1601); by the Ministry of Health, Czech Republic - conceptual development of research organization (FNBr, 65269705); by the Specific University Research (nr. MUNI/A/0968/2017) provided by MEYS; and by the project CZ.02.1.01/0.0/0.0/16_013/0001634 National Center for Medical Genomic - modernization of infrastructure and research of genetic variation in the population, funded by OP RDE. We acknowledge the CF Genomics CEITEC MU supported by the NCMG research infrastructure (LM2015091 funded by MEYS CR) for their support with obtaining the scientific data presented in this paper. We acknowledge S. Takacova from CEITEC MU for her help with the sample selection and processing.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Hernández-Sánchez M, Kotaskova J, Rodríguez AE, Radova L, Tamborero D, Abáigar M. et al. CLL cells cumulate genetic aberrations prior to the first therapy even in outwardly inactive disease phase. Leukemia. 2019 Feb;33(2):518-558. DOI: 10.1038/s41375-018-0255-1
  • dc.identifier.doi http://dx.doi.org/10.1038/s41375-018-0255-1
  • dc.identifier.issn 0887-6924
  • dc.identifier.uri http://hdl.handle.net/10230/41729
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Leukemia. 2019 Feb;33(2):518-58
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/306242
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2015–74072-JUN
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/306242
  • dc.rights This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.other Leucèmia
  • dc.title CLL cells cumulate genetic aberrations prior to the first therapy even in outwardly inactive disease phase
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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