Association between dietary fibre intake and fruit, vegetable or whole-grain consumption and the risk of CVD: results from the PREvención con DIeta MEDiterránea (PREDIMED) trial

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Buil-Cosiales, Pilarca
• dc.contributor.author Fitó Colomer, Montserratca
• dc.contributor.author PREDIMED investigatorsca
• dc.date.accessioned 2017-11-27T08:42:00Z
• dc.date.available 2017-11-27T08:42:00Z
• dc.date.issued 2016
• dc.description.abstract Prospective studies assessing the association between fibre intake or fibre-rich food consumption and the risk of CVD have often been limited by baseline assessment of diet. Thus far, no study has used yearly repeated measurements of dietary changes during follow-up. Moreover, previous studies included healthy and selected participants who did not represent subjects at high cardiovascular risk. We used yearly repeated measurements of diet to investigate the association between fibre intake and CVD in a Mediterranean cohort of elderly adults at high cardiovascular risk. We followed-up 7216 men (55-80 years) and women (60-80 years) initially free of CVD for up to 7 years in the PREvención con DIeta MEDiterránea study (registered as ISRCTN35739639). A 137-item validated FFQ was repeated yearly to assess diet. The primary end point, confirmed by a blinded ad hoc Event Adjudication Committee, was a composite of cardiovascular death, myocardial infarction and stroke. Time-dependent Cox's regression models were used to estimate the risk of CVD according to baseline dietary exposures and to their yearly updated changes. We found a significant inverse association for fibre (P for trend=0·020) and fruits (P for trend=0·024) in age-sex adjusted models, but the statistical significance was lost in fully adjusted models. However, we found a significant inverse association with CVD incidence for the sum of fruit and vegetable consumption. Participants who consumed in total nine or more servings/d of fruits plus vegetables had a hazard ratio 0·60 (95 % CI 0·40, 0·96) of CVD in comparison with those consuming <5 servings/d.
• dc.description.sponsorship The study was financially supported by the official funding agency for biomedical research of the Spanish government, Instituto de Salud Carlos III (ISCIII), through grants provided to G03/140, to RE; RTIC RD 06/0045, to MAM-G) and through Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), and by grants from Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007), the Fondo de Investigación Sanitaria–Fondo Europeo de Desarrollo Regional (Proyecto de Investigación (PI) 04-2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/ 0473, PI10/01407, PI10/02658, PI11/01647, P11/02505 and PI13/00462), the Ministerio de Ciencia e Innovación (Recursos y teconologia agroalimentarias (AGL)-2009-13906-C02 and AGL2010-22319-C03 and AGL2013-49083-C3-1-R), the Fundación Mapfre 2010, the Consejería de Salud de la Junta de Andalucía (PI0105/2007), the Public Health Division of the Department of Health of the Autonomous Government of Catalonia, the Generalitat Valenciana (Generalitat Valenciana Ayuda Complementatia (GVACOMP) 06109, GVACOMP2010-181, GVACOMP2011-151), Conselleria de Sanitat y AP; Atención Primaria (CS) 2010-AP-111, and CS2011-AP-042) and Regional Government of Navarra (P27/2011).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Buil-Cosiales P, Toledo E, Salas-Salvadó J, Zazpe I1, Farràs M, Basterra-Gortari FJ. Et al. Association between dietary fibre intake and fruit, vegetable or whole-grain consumption and the risk of CVD: results from the PREvención con DIeta MEDiterránea (PREDIMED) trial. Br J Nutr. 2016 Aug;116(3):534-46. DOI: 10.1017/S0007114516002099
• dc.identifier.doi http://dx.doi.org/10.1017/S0007114516002099
• dc.identifier.issn 0007-1145
• dc.identifier.uri http://hdl.handle.net/10230/33339
• dc.language.iso eng
• dc.publisher Cambridge University Pressca
• dc.relation.ispartof British Journal of Nutrition. 2016 Aug;116(3):534-46
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2009-13906-C02
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2010-22319-C03
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/AGL2013-49083-C3-1-R
• dc.rights © Cambridge University Press. The published version of the article: Buil-Cosiales P, Toledo E, Salas-Salvadó J, Zazpe I1, Farràs M, Basterra-Gortari FJ. Et al. Association between dietary fibre intake and fruit, vegetable or whole-grain consumption and the risk of CVD: results from the PREvención con DIeta MEDiterránea (PREDIMED) trial. Br J Nutr. 2016 Aug;116(3):534-46. is available at https://www.cambridge.org/core/journals/british-journal-of-nutrition.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Dietary fibre
• dc.subject.keyword Fruit consumption
• dc.subject.keyword Hazard ratios
• dc.subject.keyword Myocardial infarction
• dc.subject.keyword Type 2 diabetes
• dc.subject.keyword Primary prevention
• dc.subject.other Dieta -- Mediterrània, Regió de la
• dc.subject.other Infart de miocardi -- Factors de risc
• dc.title Association between dietary fibre intake and fruit, vegetable or whole-grain consumption and the risk of CVD: results from the PREvención con DIeta MEDiterránea (PREDIMED) trialca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion