From cell states to cell fates: how cell proliferation and neuronal differentiation are coordinated during embryonic development

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• dc.contributor.author Belmonte Mateos, Carla, 1992-
• dc.contributor.author Pujades Corbi, Cristina
• dc.date.accessioned 2022-02-15T06:47:16Z
• dc.date.available 2022-02-15T06:47:16Z
• dc.date.issued 2022
• dc.description.abstract The central nervous system (CNS) exhibits an extraordinary diversity of neurons, with the right cell types and proportions at the appropriate sites. Thus, to produce brains with specific size and cell composition, the rates of proliferation and differentiation must be tightly coordinated and balanced during development. Early on, proliferation dominates; later on, the growth rate almost ceases as more cells differentiate and exit the cell cycle. Generation of cell diversity and morphogenesis takes place concomitantly. In the vertebrate brain, this results in dramatic changes in the position of progenitor cells and their neuronal derivatives, whereas in the spinal cord morphogenetic changes are not so important because the structure mainly grows by increasing its volume. Morphogenesis is under control of specific genetic programs that coordinately unfold over time; however, little is known about how they operate and impact in the pools of progenitor cells in the CNS. Thus, the spatiotemporal coordination of these processes is fundamental for generating functional neuronal networks. Some key aims in developmental neurobiology are to determine how cell diversity arises from pluripotent progenitor cells, and how the progenitor potential changes upon time. In this review, we will share our view on how the advance of new technologies provides novel data that challenge some of the current hypothesis. We will cover some of the latest studies on cell lineage tracing and clonal analyses addressing the role of distinct progenitor cell division modes in balancing the rate of proliferation and differentiation during brain morphogenesis. We will discuss different hypothesis proposed to explain how progenitor cell diversity is generated and how they challenged prevailing concepts and raised new questions.
• dc.description.sponsorship This work was funded by grant PGC2018-095663-B-I00 from Ministry of Science and Innovation (MICIN), Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER) to CP. DCEXS-UPF is a Unidad de Excelencia María de Maeztu funded by the AEI (CEX2018-000792-M). CB-M is a recipient of a predoctoral FPI fellowship from the MICIN. CP is a recipient of ICREA Academia award (Generalitat de Catalunya).
• dc.format.mimetype application/pdf
• dc.identifier.citation Belmonte-Mateos C, Pujades C. From cell states to cell fates: how cell proliferation and neuronal differentiation are coordinated during embryonic development. Front Neurosci. 2022;15:781160. DOI: 10.3389/fnins.2021.781160
• dc.identifier.doi http://dx.doi.org/10.3389/fnins.2021.781160
• dc.identifier.issn 1662-4548
• dc.identifier.uri http://hdl.handle.net/10230/52491
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Front Neurosci. 2022;15:781160
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-095663-B-I00
• dc.rights © 2022 Belmonte-Mateos and Pujades. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cell fate
• dc.subject.keyword Cell state
• dc.subject.keyword Morphogenesis
• dc.subject.keyword Neural stem cells (NSC)
• dc.subject.keyword Neurogenesis
• dc.subject.keyword Neuronal differentiation
• dc.title From cell states to cell fates: how cell proliferation and neuronal differentiation are coordinated during embryonic development
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion