Serum osteoprotegerin in prevalent hemodialysis patients: associations with mortality, atherosclerosis and cardiac function

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Collado Nieto, Silviaca
• dc.contributor.author Coll, Elisabethca
• dc.contributor.author Nicolau, Carlosca
• dc.contributor.author Azqueta, Manelca
• dc.contributor.author Pons, Mercedesca
• dc.contributor.author Cruzado, Josep Ma.ca
• dc.contributor.author Torre, Bernat de laca
• dc.contributor.author Deulofeu, Ramónca
• dc.contributor.author Mojal, Sergioca
• dc.contributor.author Pascual Santos, Julioca
• dc.contributor.author Cases Amenós, Aleixca
• dc.date.accessioned 2018-04-19T09:20:42Z
• dc.date.available 2018-04-19T09:20:42Z
• dc.date.issued 2017
• dc.description.abstract BACKGROUND: To assess whether serum osteoprotegerin (OPG) and/or fetuin-A predict mortality and cardiovascular (CV) morbidity and mortality in hemodialysis patients. METHODS: Multicenter, observational, prospective study that included 220 hemodialysis patients followed up for up to 6 years. Serum OPG and fetuin-A levels were measured at baseline and their possible association with clinical characteristics, CV risk biomarkers, carotid ultrasonographic findings, as well as their association with overall and CV mortality and CV events were assessed. RESULTS: During a mean follow-up of 3.22 ± 1.91 years, there were 74 deaths (33.6%) and 86 new cardiovascular events. In the Kaplan-Meier survival analysis, the highest tertile of OPG levels was associated with higher overall mortality (p = 0.005), as well as a higher, although non-significant, incidence of CV events and CV mortality. In contrast, fetuin-A levels did not predict any of these events. OPG levels were directly associated with age, the Charlson comorbidity index (CCI), prevalent cardiovascular disease, carotid intima-media thickness, adiponectin, troponin-I and brain natriuretic peptide (BNP). OPG showed a negative correlation with left ventricular ejection fraction (LVEF) and phosphate levels. In the multivariate Cox proportional hazard analysis, all-cause mortality was associated with the highest tertile of OPG (HR:1.957, p = 0.018), age (HR:1.031, p = 0.036), smoking history (HR:2.122, p = 0.005), the CCI (HR:1.254, p = 0.004), troponin-I (HR:3.894, p = 0.042), IL-18 (HR:1.061, p < 0.001) and albumin levels (HR:0.886, p < 0.001). In the bootstrapping Cox regression analysis, the best cut-off value of OPG associated with mortality was 17.69 pmol/L (95%CI: 5.1-18.02). CONCLUSIONS: OPG, but not fetuin-A levels, are independently associated with overall mortality, as well as clinical and subclinical atherosclerosis and cardiac function, in prevalent hemodialysis patients.
• dc.format.mimetype application/pdf
• dc.identifier.citation Collado S, Coll E, Nicolau C, Azqueta M, Pons M, Cruzado JM et al. Serum osteoprotegerin in prevalent hemodialysis patients: associations with mortality, atherosclerosis and cardiac function. BMC Nephrol. 2017 Sep 7;18(1):290. DOI: 10.1186/s12882-017-0701-8
• dc.identifier.doi http://dx.doi.org/10.1186/s12882-017-0701-8
• dc.identifier.issn 1471-2369
• dc.identifier.uri http://hdl.handle.net/10230/34397
• dc.language.iso eng
• dc.publisher BioMed Centralca
• dc.relation.ispartof BMC Nephrology. 2017 Sep 7;18(1):290
• dc.rights Copyright © The Author(s). 2017. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cardiac dysfunction
• dc.subject.keyword Cardiovascular disease
• dc.subject.keyword Fetuin-a
• dc.subject.keyword Hemodialysis
• dc.subject.keyword Mortality
• dc.subject.keyword Osteoprotegerin
• dc.subject.other Cor -- Malalties
• dc.subject.other Hemodiàlisi
• dc.subject.other Mortalitat
• dc.title Serum osteoprotegerin in prevalent hemodialysis patients: associations with mortality, atherosclerosis and cardiac functionca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion