The effect of borderline pulmonary hypertension on survival in chronic lung disease

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Piccari, Lucilla
• dc.contributor.author Wort, Stephen John
• dc.contributor.author Meloni, Federica
• dc.contributor.author Rizzo, Monica
• dc.contributor.author Price, Laura C.
• dc.contributor.author Martino, Lavinia
• dc.contributor.author Salvaterra, Elena
• dc.contributor.author Scelsi, Laura
• dc.contributor.author López-Meseguer, Manuel
• dc.contributor.author Blanco, Isabel
• dc.contributor.author Callari, Adriana
• dc.contributor.author Pérez González, Virginia
• dc.contributor.author Tuzzolino, Fabio
• dc.contributor.author McCabe, Colm
• dc.contributor.author Rodríguez Chiaradía, Diego Agustín
• dc.contributor.author Vitulo, Patrizio
• dc.contributor.author REHAR Registry Investigators
• dc.date.accessioned 2022-12-02T07:55:37Z
• dc.date.available 2022-12-02T07:55:37Z
• dc.date.issued 2022
• dc.description.abstract Background: the impact of the new "borderline" hemodynamic class for pulmonary hypertension (PH) (mean pulmonary artery pressure [mPAP], 21-24 mm Hg and pulmonary vascular resistance, [PVR], ≥3 wood units, [WU]) in chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) is unclear. Objectives: the aim of this study was to assess the effect of borderline PH (BLPH) on survival in COPD and ILD patients. Method: survival was analyzed from retrospective data from 317 patients in 12 centers (Italy, Spain, UK) comparing four hemodynamic groups: the absence of PH (NoPH; mPAP <21 mm Hg or 21-24 mm Hg and PVR <3 WU), BLPH (mPAP 21-24 mm Hg and PVR ≥3 WU), mild-moderate PH (MPH; mPAP 25-35 mm Hg and cardiac index [CI] ≥2 L/min/m2), and severe PH (SPH; mPAP ≥35 mm Hg or mPAP ≥25 mm Hg and CI <2 L/min/m2). Results: BLPH affected 14% of patients; hemodynamic severity did not predict survival when COPD and ILD patients were analyzed together. However, survival in the ILD cohort for any PH level was worse than in NoPH (3-year survival: NoPH 58%, BLPH 32%, MPH 28%, SPH 33%, p = 0.002). In the COPD cohort, only SPH had reduced survival compared to the other groups (3-year survival: NoPH 82%, BLPH 86%, MPH 87%, SPH 57%, p = 0.005). The mortality risk correlated significantly with mPAP in ILD (hazard ratio [HR]: 2.776, 95% CI: 2.057-3.748, p < 0.001) and notably less in COPD patients (HR: 1.015, 95% CI: 1.003-1.027, p = 0.0146). Conclusions: in ILD, any level of PH portends worse survival, while in COPD, only SPH presents a worse outcome.
• dc.format.mimetype application/pdf
• dc.identifier.citation Piccari L, Wort SJ, Meloni F, Rizzo M, Price LC, Martino L, et al. The effect of borderline pulmonary hypertension on survival in chronic lung disease. Respiration. 2022; 101(8): 717-27. DOI: 10.1159/000524263
• dc.identifier.doi http://dx.doi.org/10.1159/000524263
• dc.identifier.issn 0025-7931
• dc.identifier.uri http://hdl.handle.net/10230/55077
• dc.language.iso eng
• dc.publisher Karger (S. Karger AG)
• dc.rights Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) http://creativecommons.org/licenses/by/4.0/ . Usage and distribution for commercial purposes requires written permission.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Borderline pulmonary hypertension
• dc.subject.keyword Chronic lung disease
• dc.subject.keyword Chronic obstructive pulmonary disease
• dc.subject.keyword Interstitial lung disease
• dc.subject.keyword Survival
• dc.title The effect of borderline pulmonary hypertension on survival in chronic lung disease
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion