Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

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• dc.contributor.author Harris, William S.
• dc.contributor.author Sala Vila, Aleix
• dc.contributor.author The Fatty Acids and Outcomes Research Consortium (FORCE)
• dc.date.accessioned 2021-10-26T05:58:13Z
• dc.date.available 2021-10-26T05:58:13Z
• dc.date.issued 2021
• dc.description.abstract The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15-18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.
• dc.format.mimetype application/pdf
• dc.identifier.citation Harris WS, Tintle NL, Imamura F, Qian F, Korat AVA, Marklund M et al. Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies. Nat Commun. 2021;12(1):2329. DOI: 10.1038/s41467-021-22370-2
• dc.identifier.doi http://dx.doi.org/10.1038/s41467-021-22370-2
• dc.identifier.issn 2041-1723
• dc.identifier.uri http://hdl.handle.net/10230/48807
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nat Commun. 2021;12(1):2329
• dc.rights © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Predictive markers
• dc.subject.keyword Risk factors
• dc.title Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion