The importance of adequate recognition of normal and dysplastic myelopoiesis for the diagnosis of myelodysplastic syndromes

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• dc.contributor.author Florensa Brichs, Lourdes
• dc.contributor.author Arenillas Rocha, Leonor
• dc.contributor.author Calvo Gonzalo, Xavier
• dc.contributor.author Pérez-Vila, Encarnación
• dc.contributor.author Ferrer Del Alamo, Ana
• dc.contributor.author Woessner, Soledad
• dc.date.accessioned 2020-01-24T07:47:45Z
• dc.date.available 2020-01-24T07:47:45Z
• dc.date.issued 2019
• dc.description.abstract The diagnosis of myelodysplastic syndromes is based on the presence of cytopenias, dysplastic morphological features on peripheral blood (PB) and bone marrow (BM), cytogenetic abnormalities and requires to rule out other diseases resembling these conditions. Optical cytomorphology is the cornerstone of diagnosis of MDS. The recognition of cytological myelodysplasia has a crucial value in diagnosis and prognosis of MDS. Assessment of cytological morphology requires, like other diagnostic techniques (flow cytometry, cytogenetics, histological morphology), experienced observers and the availability of high quality and properly stained samples. The morphological analysis has shown moderate reproducibility among hematopathologists. The better characterization and standardization of morphological features has improved the reliability and reproducibility of MDS diagnosis. Maintaining the competence in morphology assessment requires experience and continuous training. For the correct assessment of cytologic myelodysplasia it is essential to keep in mind the morphology of normal myelopoiesis. To the extent of our knowledge there are no studies describing together morphological data on normal and dysplastic myelopoiesis in the framework of MDS. Therefore, by combining these data, this manuscript could serve as a useful tool for quotidian process of diagnosis.
• dc.format.mimetype application/pdf
• dc.identifier.citation Florensa L, Arenillas L, Calvo X, Pérez-Vila E, Montesdeoca S, Ferrer A. et al. The importance of adequate recognition of normal and dysplastic myelopoiesis for the diagnosis of myelodysplastic syndromes. Histol Histopathol. 2019 Aug;34(8):857-873. DOI 10.14670/HH-18-093
• dc.identifier.doi http://dx.doi.org/10.14670/HH-18-093
• dc.identifier.issn 0213-3911
• dc.identifier.uri http://hdl.handle.net/10230/43402
• dc.language.iso eng
• dc.publisher Universidad de Murcia
• dc.rights This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. https://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Dysplastic myelopoiesis
• dc.subject.keyword Myelodysplastic syndromes
• dc.title The importance of adequate recognition of normal and dysplastic myelopoiesis for the diagnosis of myelodysplastic syndromes
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion