Ionising radiation and risk of death from leukaemia and lymphoma in radiation-monitored workers (INWORKS): an international cohort study

Leuraud, Klervi; Richardson, David B.; Cardis, Elisabeth; Daniels, Robert D.; Gillies, Michael; O’Hagan, Jacqueline A.; Hamra, Ghassan B.; Haylock, Richard; Laurier, Dominique; Moissonnier, Monika; Schubauer-Berigan, Mary K.; Thierry-Chef, Isabelle; Kesminiene, Ausrele

Ionising radiation and risk of death from leukaemia and lymphoma in radiation-monitored workers (INWORKS): an international cohort study

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dc.contributor.author Leuraud, Klervi
dc.contributor.author Richardson, David B.
dc.contributor.author Cardis, Elisabeth
dc.contributor.author Daniels, Robert D.
dc.contributor.author Gillies, Michael
dc.contributor.author O’Hagan, Jacqueline A.
dc.contributor.author Hamra, Ghassan B.
dc.contributor.author Haylock, Richard
dc.contributor.author Laurier, Dominique
dc.contributor.author Moissonnier, Monika
dc.contributor.author Schubauer-Berigan, Mary K.
dc.contributor.author Thierry-Chef, Isabelle
dc.contributor.author Kesminiene, Ausrele
dc.date.accessioned 2024-02-20T07:15:51Z
dc.date.available 2024-02-20T07:15:51Z
dc.date.issued 2015
dc.description Includes supplementary materials for online appendix.
dc.description.abstract Background. There is much uncertainty about the risks of leukaemia and lymphoma after repeated or protracted low-dose radiation exposure typical of occupational, environmental, and diagnostic medical settings. We quantified associations between protracted low-dose radiation exposures and leukaemia, lymphoma, and multiple myeloma mortality among radiation-monitored adults employed in France, the UK, and the USA. Methods. We assembled a cohort of 308 297 radiation-monitored workers employed for at least 1 year by the Atomic Energy Commission, AREVA Nuclear Cycle, or the National Electricity Company in France, the Departments of Energy and Defence in the USA, and nuclear industry employers included in the National Registry for Radiation Workers in the UK. The cohort was followed up for a total of 8·22 million person-years. We ascertained deaths caused by leukaemia, lymphoma, and multiple myeloma. We used Poisson regression to quantify associations between estimated red bone marrow absorbed dose and leukaemia and lymphoma mortality. Findings. Doses were accrued at very low rates (mean 1·1 mGy per year, SD 2·6). The excess relative risk of leukaemia mortality (excluding chronic lymphocytic leukaemia) was 2·96 per Gy (90% CI 1·17–5·21; lagged 2 years), most notably because of an association between radiation dose and mortality from chronic myeloid leukaemia (excess relative risk per Gy 10·45, 90% CI 4·48–19·65). Interpretation. This study provides strong evidence of positive associations between protracted low-dose radiation exposure and leukaemia.
dc.format.mimetype application/pdf
dc.identifier.citation Leuraud K, Richardson DB, Cardis E, Daniels RD, Gillies M, O'Hagan JA, et al. Ionising radiation and risk of death from leukaemia and lymphoma in radiation-monitored workers (INWORKS): an international cohort study. The Lancet Haematology. 2015 Jul;2(7):e276-81. DOI: 10.1016/S2352-3026(15)00094-0
dc.identifier.doi http://dx.doi.org/10.1016/S2352-3026(15)00094-0
dc.identifier.issn 2352-3026
dc.identifier.uri http://hdl.handle.net/10230/59152
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof The Lancet Haematology. 2015 Jul;2(7):e276-81
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.other Radiació ionitzant
dc.subject.other Leucèmia
dc.subject.other Limfomes
dc.title Ionising radiation and risk of death from leukaemia and lymphoma in radiation-monitored workers (INWORKS): an international cohort study
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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