Correlation of RECIST, computed tomography morphological response, and pathological regression in hepatic metastasis secondary to colorectal cancer: the AVAMET study

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• dc.contributor.author Vera, Ruth
• dc.contributor.author Montagut Viladot, Clara
• dc.contributor.author Viúdez, Antonio
• dc.date.accessioned 2021-06-07T07:30:53Z
• dc.date.available 2021-06-07T07:30:53Z
• dc.date.issued 2020
• dc.description.abstract Background: The prospective phase IV AVAMET study was undertaken to correlate response evaluation criteria in solid tumors (RECIST)-defined response rates with computed tomography-based morphological criteria (CTMC) and pathological response after liver resection of colorectal cancer metastases. Methods: Eligible patients were aged ≥18 years, with Eastern Cooperative Oncology Group (ECOG) performance status 0/1 and histologically-confirmed colon or rectal adenocarcinoma with measurable liver metastases. Preoperative treatment was bevacizumab (7.5 mg on day 1) + XELOX (oxaliplatin 130 mg/m2, capecitabine 1000 mg/m2 bid on days 1-14 q3w). After three cycles, response was evaluated by a multidisciplinary team. Patients who were progression-free and metastasectomy candidates received one cycle of XELOX before undergoing surgery 3-5 weeks later, followed by four cycles of bevacizumab + XELOX. Results: A total of 83 patients entered the study; 68 were eligible for RECIST, 67 for CTMC, and 51 for pathological response evaluation. Of these patients, 49% had a complete or partial RECIST response, 91% had an optimal or incomplete CTMC response, and 81% had a complete or major pathological response. CTMC response predicted 37 of 41 pathological responses versus 23 of 41 responses predicted using RECIST (p = 0.008). Kappa coefficients indicated a lack of correlation between the results of RECIST and morphological responses and between morphological and pathological response rates. Conclusion: CTMC may represent a better marker of pathological response to bevacizumab + XELOX than RECIST in patients with potentially-resectable CRC liver metastases.
• dc.format.mimetype application/pdf
• dc.identifier.citation Vera R, Gómez ML, Ayuso JR, Figueras J, García-Alfonso P, Martínez V, Lacasta A, et al. Correlation of RECIST, computed tomography morphological response, and pathological regression in hepatic metastasis secondary to colorectal cancer: the AVAMET study. Cancers (Basel). 2020 Aug 12; 12(8): 2259. DOI: 10.3390/cancers12082259
• dc.identifier.doi http://dx.doi.org/10.3390/cancers12082259
• dc.identifier.issn 2072-6694
• dc.identifier.uri http://hdl.handle.net/10230/47779
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights © Vera R, Gómez ML, Ayuso JR, Figueras J, García-Alfonso P, Martínez V, Lacasta A, et al. by the authors. Licensee MDPI, Basel, Switzerland. This article is an Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Antiangiogenics
• dc.subject.keyword Bevacizumab
• dc.subject.keyword Computed tomography-based morphological criteria
• dc.subject.keyword Metastatic colorectal cancer
• dc.subject.keyword Neoadjuvant chemotherapy
• dc.title Correlation of RECIST, computed tomography morphological response, and pathological regression in hepatic metastasis secondary to colorectal cancer: the AVAMET study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion