Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis.

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Baena Díez, Jose M.ca
  • dc.contributor.author Frances, Albertca
  • dc.contributor.author Grau Magaña, Mariaca
  • dc.contributor.author FRESCO Investigatorsca
  • dc.date.accessioned 2017-03-20T08:08:09Z
  • dc.date.available 2017-03-20T08:08:09Z
  • dc.date.issued 2016
  • dc.description.abstract OBJECTIVE: Diabetes is a common cause of shortened life expectancy. We aimed to assess the association between diabetes and cause-specific death. RESEARCH DESIGN AND METHODS: We used the pooled analysis of individual data from 12 Spanish population cohorts with 10-year follow-up. Participants had no previous history of cardiovascular diseases and were 35-79 years old. Diabetes status was self-reported or defined as glycemia >125 mg/dL at baseline. Vital status and causes of death were ascertained by medical records review and linkage with the official death registry. The hazard ratios and cumulative mortality function were assessed with two approaches, with and without competing risks: proportional subdistribution hazard (PSH) and cause-specific hazard (CSH), respectively. Multivariate analyses were fitted for cardiovascular, cancer, and noncardiovascular noncancer deaths. RESULTS: We included 55,292 individuals (15.6% with diabetes and overall mortality of 9.1%). The adjusted hazard ratios showed that diabetes increased mortality risk: 1) cardiovascular death, CSH = 2.03 (95% CI 1.63-2.52) and PSH = 1.99 (1.60-2.49) in men; and CSH = 2.28 (1.75-2.97) and PSH = 2.23 (1.70-2.91) in women; 2) cancer death, CSH = 1.37 (1.13-1.67) and PSH = 1.35 (1.10-1.65) in men; and CSH = 1.68 (1.29-2.20) and PSH = 1.66 (1.25-2.19) in women; and 3) noncardiovascular noncancer death, CSH = 1.53 (1.23-1.91) and PSH = 1.50 (1.20-1.89) in men; and CSH = 1.89 (1.43-2.48) and PSH = 1.84 (1.39-2.45) in women. In all instances, the cumulative mortality function was significantly higher in individuals with diabetes. CONCLUSIONS: Diabetes is associated with premature death from cardiovascular disease, cancer, and noncardiovascular noncancer causes. The use of CSH and PSH provides a comprehensive view of mortality dynamics in a population with diabetes.ca
  • dc.description.sponsorship This work was supported by MARATO TV3 (081630), Instituto de Salud Carlos III–Fondo Europeo de Desarrollo Regional–European Regions Development Funds (Red de Investigación Cardiovascular RD12/0042 [Programa HERACLES], Red RedIAPP RD12/0005, RD06/0018, PI081327, and PI1101801), Agency for Management of University and Research Grants (2014 SGR 240), Consortium for Biomedical Research in Epidemiology and Public Health, and Consortium for Biomedical Research in Obesity and Nutrition. M.G. was supported by the Instituto de Salud Carlos III– Fondo Europeo de Desarrollo Regional–European Regions Development Fund FEDER (FIS CP12/ 03287).
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Baena-Díez JM, Peñafiel J, Subirana I, Ramos R, Elosua R, Marín-Ibañez A. et al. Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis. Diabetes Care. 2016 Nov;39(11):1987-1995.ca
  • dc.identifier.doi http://dx.doi.org/10.2337/dc16-0614
  • dc.identifier.issn 0149-5992
  • dc.identifier.uri http://hdl.handle.net/10230/28258
  • dc.language.iso engca
  • dc.publisher American Diabetes Associationca
  • dc.relation.ispartof Diabetes Care. 2016 Nov;39(11):1987-95.
  • dc.rights © American Diabetes Association. This is an author-created, uncopyedited electronic version of an article accepted for publication in Diabetes Care. The American Diabetes Association (ADA), publisher of Diabetes Care, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online at http://diabetes.diabetesjournals.org.ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.subject.other Diabetisca
  • dc.subject.other Sistema cardiovascular -- Malalties -- Mortalitatca
  • dc.subject.other Càncer -- Mortalitatca
  • dc.title Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis.ca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/acceptedVersionca

Col·leccions

Articles (Hospital del Mar Research Institute)