Postnatal environmental enrichment enhances memory through distinct neural mechanisms in healthy and trisomic female mice

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• dc.contributor.author Alemany González, Maria, 1991-
• dc.contributor.author Vilademunt Alcaide, Marta
• dc.contributor.author Gener, Thomas
• dc.contributor.author Puig Velasco, María Victoria
• dc.date.accessioned 2023-02-09T08:07:28Z
• dc.date.available 2023-02-09T08:07:28Z
• dc.date.issued 2022
• dc.description.abstract Stimulating lifestyles have powerful effects on cognitive abilities, especially when they are experienced early in life. Cognitive therapies are widely used to improve cognitive impairment due to intellectual disability, aging, and neurodegeneration, however the underlying neural mechanisms are poorly understood. We investigated the neural correlates of memory amelioration produced by postnatal environmental enrichment (EE) in diploid mice and the Ts65Dn mouse model of Down syndrome (trisomy 21). We recorded neural activities in brain structures key for memory processing, the hippocampus and the prefrontal cortex, during rest, sleep and memory performance in mice reared in non-enriched or enriched environments. Enriched wild-type animals exhibited enhanced neural synchrony in the hippocampus across different brain states (increased gamma oscillations, theta-gamma coupling, sleep ripples). Trisomic females showed increased theta and gamma rhythms in the hippocampus and prefrontal cortex across different brain states along with enlarged ripples and disrupted circuit gamma signals that were associated with memory deficits. These pathological activities were attenuated in their trisomic EE-reared peers. Our results suggest distinct neural mechanisms for the generation and rescue of healthy and pathological brain synchrony, respectively, by EE and put forward hippocampal-prefrontal hypersynchrony and miscommunication as major targets underlying the beneficial effects of EE in intellectual disability.
• dc.description.sponsorship This work was supported by the Jerome Lejeune Foundation (grant #1419) and by the Spanish government grants SAF2016-80726-R and PID2019-104683RB-I00 funded by MCIN/AEI/10.13039/501100011033 and by ERDF “A way of making Europe”.
• dc.format.mimetype application/pdf
• dc.identifier.citation Alemany-González M, Vilademunt M, Gener T, Puig MV. Postnatal environmental enrichment enhances memory through distinct neural mechanisms in healthy and trisomic female mice. Neurobiol Dis. 2022 Oct 15;173:105841. DOI: 10.1016/j.nbd.2022.105841
• dc.identifier.doi http://dx.doi.org/10.1016/j.nbd.2022.105841
• dc.identifier.issn 0969-9961
• dc.identifier.uri http://hdl.handle.net/10230/55685
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Neurobiol Dis. 2022 Oct 15;173:105841
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-80726-R
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-104683RB-I00
• dc.rights © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by- nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Cognitive stimulation
• dc.subject.keyword Down syndrome
• dc.subject.keyword Functional connectivity
• dc.subject.keyword Hippocampus
• dc.subject.keyword Intellectual disability
• dc.subject.keyword Memory impairment
• dc.subject.keyword Neural synchrony
• dc.subject.keyword Prefrontal cortex
• dc.subject.keyword REM sleep
• dc.subject.keyword Ts65Dn Genetic mouse model
• dc.title Postnatal environmental enrichment enhances memory through distinct neural mechanisms in healthy and trisomic female mice
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion