Traffic pollution exposure is associated with altered brain connectivity in school children.
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Pujol Martí, Jesús, 1981-ca
- dc.contributor.author Martínez-Vilavella, Gerardca
- dc.contributor.author Macià, Dídacca
- dc.contributor.author Fenoll, Raquelca
- dc.contributor.author Álvarez Pedrerol, Marca
- dc.contributor.author Rivas, Ioarca
- dc.contributor.author Forns i Guzman, Joan, 1981-ca
- dc.contributor.author Blanco Hinojo, Laura, 1981-ca
- dc.contributor.author Capellades Font, Jaumeca
- dc.contributor.author Querol, Xavierca
- dc.contributor.author Deus, Joanca
- dc.contributor.author Sunyer Deu, Jordica
- dc.date.accessioned 2016-05-05T10:42:16Z
- dc.date.issued 2016
- dc.description.abstract Children are more vulnerable to the effects of environmental elements due to their active developmental processes. Exposure to urban air pollution has been associated with poorer cognitive performance, which is thought to be a result of direct interference with brain maturation. We aimed to assess the extent of such potential effects of urban pollution on child brain maturation using general indicators of vehicle exhaust measured in the school environment and a comprehensive imaging evaluation. A group of 263 children, aged 8 to 12years, underwent MRI to quantify regional brain volumes, tissue composition, myelination, cortical thickness, neural tract architecture, membrane metabolites, functional connectivity in major neural networks and activation/deactivation dynamics during a sensory task. A combined measurement of elemental carbon and NO2 was used as a putative marker of vehicle exhaust. Air pollution exposure was associated with brain changes of a functional nature, with no evident effect on brain anatomy, structure or membrane metabolites. Specifically, a higher content of pollutants was associated with lower functional integration and segregation in key brain networks relevant to both inner mental processes (the default mode network) and stimulus-driven mental operations. Age and performance (motor response speed) both showed the opposite effect to that of pollution, thus indicating that higher exposure is associated with slower brain maturation. In conclusion, urban air pollution appears to adversely affect brain maturation in a critical age with changes specifically concerning the functional domain.ca
- dc.description.sponsorship This work was supported by the European Research Council under the ERC [grant number 268479]—the BREATHE project. The Agency of University and Research Funding Management of the Catalonia Government participated in the context of Research Group SGR2014-1673.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Pujol J, Martínez-Vilavella G, Macià D, Fenoll R, Alvarez-Pedrerol M, Rivas I. et al. Traffic pollution exposure is associated with altered brain connectivity in school children. Neuroimage. 2016 Apr 1;129:175-84. DOI: 10.1016/j.neuroimage.2016.01.036ca
- dc.identifier.doi http://dx.doi.org/10.1016/j.neuroimage.2016.01.036
- dc.identifier.issn 1053-8119
- dc.identifier.uri http://hdl.handle.net/10230/26247
- dc.language.iso engca
- dc.publisher Elsevierca
- dc.relation.ispartof Neuroimage. 2016 Apr 1;129:175-84
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/268479
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.neuroimage.2016.01.036ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Aire -- Contaminacióca
- dc.subject.other Infants -- Desenvolupamentca
- dc.title Traffic pollution exposure is associated with altered brain connectivity in school children.ca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca