Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries

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• dc.contributor.author Piperni, Elisa
• dc.contributor.author Vallès Colomer, Mireia
• dc.contributor.author Asnicar, Francesco
• dc.date.accessioned 2024-09-20T06:07:20Z
• dc.date.available 2024-09-20T06:07:20Z
• dc.date.issued 2024
• dc.description.abstract Diet impacts human health, influencing body adiposity and the risk of developing cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but while its bacterial fraction is widely studied, the role of micro-eukaryotes, including Blastocystis, is underexplored. We performed a global-scale analysis on 56,989 metagenomes and showed that human Blastocystis exhibits distinct prevalence patterns linked to geography, lifestyle, and dietary habits. Blastocystis presence defined a specific bacterial signature and was positively associated with more favorable cardiometabolic profiles and negatively with obesity (p < 1e-16) and disorders linked to altered gut ecology (p < 1e-8). In a diet intervention study involving 1,124 individuals, improvements in dietary quality were linked to weight loss and increases in Blastocystis prevalence (p = 0.003) and abundance (p < 1e-7). Our findings suggest a potentially beneficial role for Blastocystis, which may help explain personalized host responses to diet and downstream disease etiopathogenesis.
• dc.description.sponsorship We thank the participants of the PREDICT program. This work was supported by Zoe Ltd. and TwinsUK, which are funded by the Wellcome Trust, Medical Research Council, Versus Arthritis, European Union Horizon 2020, Chronic Disease Research Foundation, the National Institute for Health Research Clinical Research Network, and the Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London. It was partially supported by the American Gastroenterological Association Research Foundation’s Research Scholars Award to L.H.N., the Crohn’s and Colitis Foundation Career Development Award to L.H.N., and NIH/NIDDK K23DK125838 to L.H.N. L.H.N. is the Massachusetts General Hospital/Chen Institute Transformative Scholar in Medicine. The study was supported by the European Research Council (ERC-STG project MetaPG-716575 and ERC-CoG microTOUCH-101045015) to N.S., by the European Union’s Horizon 2020 program (ONCOBIOME-825410 project, MASTER- 818368 project, and IHMCSA-964590) to N.S., by the European Union’s Horizon Europe program (DOMINO-101060218), by the European Union NextGenerationEU (INEST) to N.S., by the National Cancer Institute of the National Institutes of Health (1U01CA230551) to N.S. and R35 CA253178 to A.T.C., and by the Premio Internazionale Lombardia e Ricerca 2019 to N.S. The MBS and MLVS were supported by NIH U01CA176726 and U01CA167552. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The Lifelines Biobank initiative has been made possible by the Dutch Ministry of Health, Welfare, and Sport; the Dutch Ministry of Economic Affairs; the University Medical Center Groningen; the University of Groningen; and the Northern Provinces of the Netherlands. The authors acknowledge the services of the Lifelines Cohort Study, the contributing research centers delivering data to Lifelines, and all the study participants. J.F. is supported by the Dutch Heart Foundation IN-CONTROL (CVON2018-27), the ERC-CoG (No.101001678), NWO-VICI grant VI.C.202.022, the AMMODO Science Award 2023 for Biomedical Sciences from Stichting Ammodo, and the Netherlands Organ-on-Chip Initiative, an NWO Gravitation project (024.003.001) funded by the Ministry of Education, Culture, and Science of The Netherlands. A.Z. is supported by the Dutch Heart Foundation IN-CONTROL (CVON2018-27), the ERC-StG (No. 715772), NWO-VIDI grant 016.178.056, and the NWO Gravitation grant Exposome-NL (024.004.017). A.T.C. is partially supported by an American Cancer Society Research Professor Award.
• dc.format.mimetype application/pdf
• dc.identifier.citation Piperni E, Nguyen LH, Manghi P, Kim H, Pasolli E, Andreu-Sánchez S, et al. Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries. Cell. 2024 Aug 22;187(17):4554-4570.e18. DOI: 10.1016/j.cell.2024.06.018
• dc.identifier.doi http://dx.doi.org/10.1016/j.cell.2024.06.018
• dc.identifier.issn 0092-8674
• dc.identifier.uri http://hdl.handle.net/10230/61188
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Cell. 2024 Aug 22;187(17):4554-4570.e18
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/716575
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101045015
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/825410
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/818368
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/964590
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101060218
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101001678
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/715772
• dc.rights © 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Blastocystis hominis
• dc.subject.keyword Cardiometabolic health
• dc.subject.keyword Diet and microbiome
• dc.subject.keyword Human gut microbiome
• dc.subject.keyword Integrative metagenomics
• dc.subject.keyword Metagenomics
• dc.subject.keyword Micro-eukaryote
• dc.subject.keyword Microbiome meta-analysis
• dc.subject.keyword Transkingdom microbiome analysis
• dc.title Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion