The presence of human herpesvirus 6 in the brain in health and disease
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- dc.contributor.author Santpere Baró, Gabriel, 1981-
- dc.contributor.author Telford, Marco, 1984-
- dc.contributor.author Andrés Benito, Pol
- dc.contributor.author Navarro i Cuartiellas, Arcadi, 1969-
- dc.contributor.author Ferrer, Isidre
- dc.date.accessioned 2020-12-09T07:40:27Z
- dc.date.available 2020-12-09T07:40:27Z
- dc.date.issued 2020
- dc.description.abstract The human herpesvirus 6 (HHV-6) -A and -B are two dsDNA beta-herpesviruses infectingalmost the entire worldwide population. These viruses have been implicated in multipleneurological conditions in individuals of various ages and immunological status, includingencephalitis, epilepsy, and febrile seizures. HHV-6s have also been suggested as playing a role inthe etiology of neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease. Theapparent robustness of these suggested associations is contingent on the accuracy of HHV-6detection in the nervous system. The effort of more than three decades of researching HHV-6 in thebrain has yielded numerous observations, albeit using variable technical approaches in terms oftissue preservation, detection techniques, sample sizes, brain regions, and comorbidities. In thisreview, we aimed to summarize current knowledge about the entry routes and direct presence ofHHV-6 in the brain parenchyma at the level of DNA, RNA, proteins, and specific cell types, inhealthy subjects and in those with neurological conditions. We also discuss recent findings relatedto the presence of HHV-6 in the brains of patients with Alzheimer's disease in light of availableevidence.
- dc.format.mimetype application/pdf
- dc.identifier.citation Santpere G, Telford M, Andrés-Benito P, Navarro A, Ferrer I. The presence of human herpesvirus 6 in the brain in health and disease. Biomolecules. 2020; 10(11):1520. DOI: 10.3390/biom10111520
- dc.identifier.doi http://dx.doi.org/10.3390/biom10111520
- dc.identifier.issn 2218-273X
- dc.identifier.uri http://hdl.handle.net/10230/45953
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Biomolecules. 2020; 10(11):1520
- dc.rights © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Alzheimer’s disease
- dc.subject.keyword Brain
- dc.subject.keyword Encephalitis
- dc.subject.keyword Epilepsy
- dc.subject.keyword Human herpesvirus 6
- dc.subject.keyword Immunohistochemistry
- dc.subject.keyword Multiple sclerosis
- dc.title The presence of human herpesvirus 6 in the brain in health and disease
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion