Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age – An exposome-based approach in 5 European cohorts

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  • dc.contributor.author Jedynak, Paulina
  • dc.contributor.author Maitre, Léa
  • dc.contributor.author Guxens Junyent, Mònica
  • dc.contributor.author Julvez, Jordi
  • dc.contributor.author López Vicente, Mònica, 1988-
  • dc.contributor.author Sunyer Deu, Jordi
  • dc.contributor.author Casas Sanahuja, Maribel
  • dc.contributor.author Tamayo-Uria, Ibon
  • dc.contributor.author Urquiza, José M.
  • dc.contributor.author Basagaña Flores, Xavier
  • dc.contributor.author Vrijheid, Martine
  • dc.contributor.author Philippat, Claire
  • dc.date.accessioned 2021-02-01T07:28:49Z
  • dc.date.available 2021-02-01T07:28:49Z
  • dc.date.issued 2021
  • dc.description.abstract Background: Studies looking at associations between environmental chemicals and child behaviour usually consider only one exposure or family of exposures. Objective: This study explores associations between prenatal exposure to a wide range of environmental chemicals and child behaviour. Methods: We studied 708 mother-child pairs from five European cohorts recruited in 2003-2009. We assessed 47 exposure biomarkers from eight chemical exposure families in maternal blood or urine collected during pregnancy. We used the Strengths and Difficulties Questionnaire (SDQ) to evaluate child behaviour between three and seven years of age. We assessed associations of SDQ scores with exposures using an adjusted least absolute shrinkage and selection operator (LASSO) considering all exposures simultaneously and an adjusted exposome-wide association study (ExWAS) considering each exposure independently. Results: LASSO selected only copper (Cu) as associated with externalizing behaviour. In the ExWAS, bisphenol A [BPA, incidence rate ratio (IRR): 1.06, 95% confidence interval (95%CI): 1.01;1.12] and mono-n-butyl phthalate (MnBP, IRR: 1.06, 95%CI: 1.00;1.13) were associated with greater risk of externalizing behaviour problems. Cu (IRR: 0.90, 95%CI: 0.82;0.98), perfluoroundecanoate (PFUnDA, IRR: 0.92, 95%CI: 0.84;0.99) and organochlorine compounds (OCs) were associated with lower risk of externalizing behaviour problems, however the associations with OCs were mainly seen among women with insufficient weight gain during pregnancy. Internalizing score worsen in association with exposure to diethyl thiophosphate (DETP, IRR: 1.11, 95%CI: 1.00;1.24) but the effect was driven by the smallest cohort. Internalizing score improved with increased concentration of perfluorooctane sulfonate (PFOS, IRR: 0.92, 95%CI: 0.85;1.00), however the association was driven by the two smallest cohorts with the lowest PFOS concentrations. Discussion: This study added evidence on deleterious effects of prenatal exposure to BPA and MnBP on child behaviour. Other associations should be interpreted cautiously since they were not consistent with previous studies or they have not been studied extensively.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Jedynak P, Maitre L, Guxens M, Gützkow KB, Julvez J, López-Vicente M et al. Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age – An exposome-based approach in 5 European cohorts. Sci Total Environ. 2021; 763:144115. DOI: 10.1016/j.scitotenv.2020.144115
  • dc.identifier.doi http://dx.doi.org/10.1016/j.scitotenv.2020.144115
  • dc.identifier.issn 0048-9697
  • dc.identifier.uri http://hdl.handle.net/10230/46300
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Sci Total Environ. 2021; 763:144115
  • dc.rights © 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Birth cohort
  • dc.subject.keyword Child behaviour
  • dc.subject.keyword Internal exposome
  • dc.subject.keyword Prenatal exposure
  • dc.subject.keyword Strengths and Difficulties Questionnaire
  • dc.title Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age – An exposome-based approach in 5 European cohorts
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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