Examining topoisomers of a snake-venom-derived peptide for improved antimicrobial and antitumoral properties

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• dc.contributor.author Carrera-Aubesart, Adam
• dc.contributor.author Defaus, Sira
• dc.contributor.author Pérez-Peinado, Clara, 1991-
• dc.contributor.author Sandín, Daniel
• dc.contributor.author Torrent Burgas, Marc
• dc.contributor.author Jiménez, M. Ángeles
• dc.contributor.author Andreu Martínez, David
• dc.date.accessioned 2022-11-15T07:08:47Z
• dc.date.available 2022-11-15T07:08:47Z
• dc.date.issued 2022
• dc.description.abstract Ctn[15-34], the C-terminal section of crotalicidin (Ctn), a cathelicidin from a South American pit viper, is an antimicrobial and antitumoral peptide with remarkably longer stability in human serum than the parent Ctn. In this work, a set of topoisomers of both Ctn and Ctn[15-34], including the retro, enantio, and retroenantio versions, were synthesized and tested to investigate the structural requirements for activity. All topoisomers were as active as the cognate sequences against Gram-negative bacteria and tumor cells while slightly more toxic towards normal cells. More importantly, the enhanced serum stability of the D-amino-acid-containing versions suggests that such topoisomers must be preferentially considered as future antimicrobial and anticancer peptide leads.
• dc.description.sponsorship Financial support from the Spanish Ministry of Economy and Innovation (grant AGL2017-84097-C2-2-R), from the Spanish Ministry of Science and Innovation (MCIN/AEI/10.13039/501100011033 grants PID2020-113184RB-C22; PID2020-112821GB-I00 and PID2020-114627RB-I00; MCIN/AEI/10.13039/501100011033/FEDER PDC2021-121544-I00), from the EU (Next GenerationEU/PRTR) and from La Caixa Banking Foundation (HR17-00409) is acknowledged.
• dc.format.mimetype application/pdf
• dc.identifier.citation Carrera-Aubesart A, Defaus S, Pérez-Peinado C, Sandín D, Torrent M, Jiménez MÁ, Andreu D. Examining topoisomers of a snake-venom-derived peptide for improved antimicrobial and antitumoral properties. Biomedicines. 2022 Aug 29;10(9):2110. DOI: 10.3390/biomedicines10092110
• dc.identifier.doi http://dx.doi.org/10.3390/biomedicines10092110
• dc.identifier.issn 2227-9059
• dc.identifier.uri http://hdl.handle.net/10230/54847
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Biomedicines. 2022 Aug 29;10(9):2110
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/AGL2017-84097-C2-2-R
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-113184RB-C22
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-112821GB-I00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-114627RB-I00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PDC2021-121544-I00
• dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Ctn[15-34]
• dc.subject.keyword Antimicrobial peptides
• dc.subject.keyword Antitumoral peptides
• dc.subject.keyword Crotalicidin
• dc.subject.keyword Enantio-, retro-, and retroenantio peptides
• dc.subject.keyword Snake venom
• dc.subject.keyword Topoisomer peptides
• dc.title Examining topoisomers of a snake-venom-derived peptide for improved antimicrobial and antitumoral properties
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion