Effects of exercise training on circulating biomarkers of endothelial function in pulmonary arterial hypertension

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• dc.contributor.author Rodríguez Chiaradía, Diego Agustín
• dc.contributor.author Khilzi, Karys
• dc.contributor.author Blanco, Isabel
• dc.contributor.author Rodó-Pin, Anna
• dc.contributor.author Martín-Ontiyuelo, Clara
• dc.contributor.author Herranz Blasco, Anna
• dc.contributor.author Garcia-Lucio, Jéssica
• dc.contributor.author Molina Ferragut, Luis
• dc.contributor.author Marco Navarro, Ester
• dc.contributor.author Barreiro Portela, Esther
• dc.contributor.author Piccari, Lucilla
• dc.contributor.author Peinado, Victor I.
• dc.contributor.author García, Agustín Roberto
• dc.contributor.author Tura-Ceide, Olga
• dc.contributor.author Barberà, Joan Albert
• dc.date.accessioned 2024-03-12T18:22:09Z
• dc.date.available 2024-03-12T18:22:09Z
• dc.date.issued 2023
• dc.description.abstract Introduction: In stable patients with pulmonary arterial hypertension (PAH), pulmonary rehabilitation (PR) is an effective, safe and cost-effective non-pharmacological treatment. However, the effects of PR on vascular function have been poorly explored. This study aimed to compare the amounts of circulating progenitor cells (PCs) and endothelial microvesicles (EMVs) in patients with PAH before and after 8 weeks of endurance exercise training as markers of vascular competence. Methods: A prospective study of 10 consecutive patients with PAH that successfully finished a PR program (8 weeks) was carried out before and after this intervention. Levels of circulating PCs defined as CD34+CD45low progenitor cells and levels of EMVs (CD31+ CD42b-) were measured by flow cytometry. The ratio of PCs to EMVs was taken as a measure of the balance between endothelial damage and repair capacity. Results: All patients showed training-induced increases in endurance time (mean change 287 s). After PR, the number of PCs (CD34+CD45low/total lymphocytes) was increased (p < 0.05). In contrast, after training, the level of EMVs (CD31+ CD42b-/total EMVs) was reduced. The ratio of PCs to EMVs was significantly higher after training (p < 0.05). Conclusion: Our study shows, for the first time, that endurance exercise training in patients with stable PAH has a positive effect, promoting potential mechanisms of damage/repair in favor of repair. This effect could contribute to a positive hemodynamic and clinical response.
• dc.format.mimetype application/pdf
• dc.identifier.citation Rodríguez-Chiaradía DA, Khilzi K, Blanco I, Rodó-Pin A, Martin-Ontiyuelo C, Herranz Blasco A, et al. Effects of exercise training on circulating biomarkers of endothelial function in pulmonary arterial hypertension. Biomedicines. 2023 Jun 25;11(7):1822. DOI: 10.3390/biomedicines11071822
• dc.identifier.doi http://dx.doi.org/10.3390/biomedicines11071822
• dc.identifier.issn 2227-9059
• dc.identifier.uri http://hdl.handle.net/10230/59391
• dc.language.iso eng
• dc.publisher BioMed Central
• dc.relation.ispartof Biomedicines. 2023 Jun 25;11(7):1822
• dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Endothelial function
• dc.subject.keyword Exercise training
• dc.subject.keyword Pulmonary hypertension
• dc.title Effects of exercise training on circulating biomarkers of endothelial function in pulmonary arterial hypertension
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion