Transcutaneous bilirubin reliability during and after phototherapy depending on skin color

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• dc.contributor.author Candel-Pau, Júlia
• dc.contributor.author Maya-Enero, Silvia
• dc.contributor.author García García, Jordi
• dc.contributor.author Duran Jordà, Xavier, 1974-
• dc.contributor.author López-Vílchez, María Ángeles
• dc.date.accessioned 2025-05-23T05:53:32Z
• dc.date.available 2025-05-23T05:53:32Z
• dc.date.issued 2024
• dc.description.abstract Measurement of transcutaneous bilirubin (TcB) is a non-invasive, widely used technique to estimate serum bilirubin (SB). However, its reliability in multiethnic populations during and after phototherapy is still controversial even in covered skin. The aim of this study was to determine the reliability of TcB in covered (cTcB) and exposed (eTcB) skin during and after phototherapy in a multiethnic population of term and preterm neonates according to Neomar's neonatal skin color scale. Prospective, observational study comparing SB and TcB. We determined SB when clinically indicated and, at the same time, measured cTcB under a photo-opaque patch and eTcB next to it with a jaundice meter (Dräger JM-105TM). All dyads TcB-SB were compared, both globally and according to skin color. We obtained data from 200 newborns (color1: 44, color2: 111, color3: 41, color4: 4) and compared 296 dyads TcB/SB. Correlation between cTcB and SB is strong during (0.74-0.83) and after (0.79-0.88) phototherapy, both globally and by color group. The SB-cTcB bias depends on gestational age during phototherapy and on skin color following phototherapy. The correlation between eTcB and SB during phototherapy is not strong (0.54), but becomes so 12 h after discontinuing phototherapy (0.78). Conclusions: Our study supports the reliability of cTcB to assess SB during and after phototherapy, with differences among skin tones after the treatment. The use of cTcB and Neomar's scale during and mainly after phototherapy may help reduce the number of blood samples required. What is Known: • Controversies exist on the reliability of jaundice meters during and after phototherapy in covered skin. Only a few studies have analyzed their accuracy in multiethnic populations, but none has used a validated neonatal skin color scale. What is New: • We verified correlation between serum and transcutaneous bilirubin in covered skin in a multiethnic population depending on skin color based on our own validated neonatal skin color scale during and after phototherapy.
• dc.format.mimetype application/pdf
• dc.identifier.citation Candel-Pau J, Maya-Enero S, Garcia-Garcia J, Duran-Jordà X, López-Vílchez MÁ. Transcutaneous bilirubin reliability during and after phototherapy depending on skin color. Eur J Pediatr. 2024 Jul;183(7):2819-30. DOI: 10.1007/s00431-024-05516-4
• dc.identifier.doi http://dx.doi.org/10.1007/s00431-024-05516-4
• dc.identifier.issn 0340-6199
• dc.identifier.uri http://hdl.handle.net/10230/70462
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Eur J Pediatr. 2024 Jul;183(7):2819-30
• dc.rights © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Hyperbilirubinemia
• dc.subject.keyword Neonatal jaundice
• dc.subject.keyword Phototherapy
• dc.subject.keyword Serum bilirubin
• dc.subject.keyword Skin color
• dc.subject.keyword Transcutaneous bilirubin
• dc.title Transcutaneous bilirubin reliability during and after phototherapy depending on skin color
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion