Extremely high levels of vancomycin can cause severe renal toxicity

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• dc.contributor.author Barceló-Vidal, Jaime
• dc.contributor.author Rodríguez García, Eva
• dc.contributor.author Grau Cerrato, Santiago
• dc.date.accessioned 2019-05-20T07:53:15Z
• dc.date.available 2019-05-20T07:53:15Z
• dc.date.issued 2018
• dc.description.abstract Vancomycin has usually been associated with nephrotoxicity. Generally, this toxicity is presented as proximal tubular cells injury with or without necrosis and as acute interstitial nephritis. However, development of both lesions is uncommonly described in literature. We present a case of vancomycin-induced nephrotoxicity resulting in both acute interstitial nephritis and tubular cells damage confirmed by renal biopsy. Peak and trough levels of 77.11 and 63.60 μg/mL, respectively, were obtained at the first plasma determination. After 8 more plasma determinations and several hemodialysis sessions, vancomycin levels were undetectable 1 month after therapy was stopped. To our knowledge, this is the case report with the highest vancomycin trough levels developing both lesions and describing total vancomycin washout after a biopsy-proven vancomycin toxicity. In conclusion, early vancomycin therapeutic drug monitoring should be performed in order to avoid toxicities where, as seen in our patient, antibiotic exposure could last around 1 month after last dose administration.
• dc.format.mimetype application/pdf
• dc.identifier.citation Barceló-Vidal J, Rodríguez-García E, Grau S. Extremely high levels of vancomycin can cause severe renal toxicity. Infect Drug Resist. 2018 Jul 30;11:1027-1030. DOI: 10.2147/IDR.S171669
• dc.identifier.doi http://dx.doi.org/10.2147/IDR.S171669
• dc.identifier.issn 1178-6973
• dc.identifier.uri http://hdl.handle.net/10230/37244
• dc.language.iso eng
• dc.publisher Dove Medical Press
• dc.relation.ispartof Infection and Drug Resistance. 2018 Jul 30;11:1027-30
• dc.rights Copyright © 2018 Barceló-Vidal et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
• dc.subject.keyword Nephrotoxicity
• dc.subject.keyword Therapeutic drug monitoring
• dc.subject.keyword Vancomycin
• dc.subject.other Ronyons -- Malalties
• dc.title Extremely high levels of vancomycin can cause severe renal toxicity
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion