The impact of additional margin coagulation with radiofrequency in liver resections with subcentimetric margin: can we improve the oncological results? A propensity score matching study

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  • dc.contributor.author Villamonte, Maria
  • dc.contributor.author Burdío Pinilla, Fernando
  • dc.contributor.author Pueyo Périz, Eva M.
  • dc.contributor.author Andaluz, Anna
  • dc.contributor.author Moll, Xavier
  • dc.contributor.author Berjano, Enrique J.
  • dc.contributor.author Radosevic, Aleksandar, 1974-
  • dc.contributor.author Grande Posa, Luís
  • dc.contributor.author Pera Roman, Miguel
  • dc.contributor.author Ielpo, Benedetto
  • dc.contributor.author Sánchez Velázquez, Patricia, 1985-
  • dc.date.accessioned 2022-02-08T06:41:14Z
  • dc.date.available 2022-02-08T06:41:14Z
  • dc.date.issued 2022
  • dc.description.abstract Background: Whereas the usefulness of radiofrequency (RF) energy as haemostatic method in liver surgery has become well established in the last decades, its intentional application on resection margins with the aim of reducing local recurrence is still debatable. Our goal was to compare the impact of an additional application of RF energy on the top of the resection surface, namely additional margin coagulation (AMC), on local recurrence (LR) when subjected to a subcentimeter margin. Methods: We retrospectively analyzed 185 patients out of a whole cohort of 283 patients who underwent radical hepatic resection with subcentimetric margin. After propensity score adjustment, patients were classified into two balanced groups according to whether RF was applied or not. Results: No significant differences were observed within groups in baseline characteristics after PSM adjustment. The LR rate was significantly higher in the Control than AMC Group: 12 patients (14.5%) vs. 4 patients (4.8%) (p = 0.039). The estimated 1, 3, and 5-year LR-free survival rates of patients in the Control and AMC Group were: 93.5%, 86.0%, 81.0% and 98.8%, 97.2%, 91.9%, respectively (p = 0.049). Univariate Cox analyses indicated that the use of the RF applicator was significantly associated with lower LR (HR = 0.29, 95% confidence interval 0.093-0.906, p = 0.033). The Control Group showed smaller coagulation widths than the AMC group (p < 0.001). Conclusions: An additional application of RF on the top of the resection surface is associated with less local hepatic recurrence than the use of conventional techniques.
  • dc.description.sponsorship This work was partially supported by the Spanish Ministerio de Ciencia, Innovación y Universidades under “Programa Estatal de I+D+i Orientada a los Retos de la Sociedad”, Grants Nº “ RTI2018-094357-B-C21 ” and “ RTI2018-094357-B-C22”.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Villamonte M, Burdío F, Pueyo E, Andaluz A, Moll X, Berjano E, Radosevic A, Grande L, Pera M, Ielpo B, Sánchez-Velázquez P. The impact of additional margin coagulation with radiofrequency in liver resections with subcentimetric margin: can we improve the oncological results? A propensity score matching study. Eur J Surg Oncol. 2022;48(1):82-8. DOI: 10.1016/j.ejso.2021.06.008
  • dc.identifier.doi http://dx.doi.org/10.1016/j.ejso.2021.06.008
  • dc.identifier.issn 0748-7983
  • dc.identifier.uri http://hdl.handle.net/10230/52434
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Eur J Surg Oncol. 2022;48(1):82-8
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-094357-B-C21
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-094357-B-C22
  • dc.rights © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Liver recurrence
  • dc.subject.keyword Margin invasion
  • dc.subject.keyword Radiofrequency ablation
  • dc.title The impact of additional margin coagulation with radiofrequency in liver resections with subcentimetric margin: can we improve the oncological results? A propensity score matching study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Hospital del Mar Research Institute)