Lack of context modulation in human single neuron responses in the medial temporal lobe
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- dc.contributor.author Rey, Hernan G.
- dc.contributor.author Panagiotaropoulos, Theofanis I.
- dc.contributor.author Gutierrez, Lorenzo
- dc.contributor.author Chaure, Fernando J.
- dc.contributor.author Nasimbera, Alejandro
- dc.contributor.author Cordisco, Santiago
- dc.contributor.author Nishida, Fabian
- dc.contributor.author Valentin, Antonio
- dc.contributor.author Alarcon, Gonzalo
- dc.contributor.author Richardson, Mark P.
- dc.contributor.author Kochen, Silvia
- dc.contributor.author Quian Quiroga, Rodrigo
- dc.date.accessioned 2025-10-24T16:50:01Z
- dc.date.available 2025-10-24T16:50:01Z
- dc.date.issued 2025
- dc.date.updated 2025-10-24T16:50:01Z
- dc.description.abstract In subjects implanted with intracranial electrodes, we use two different stories involving the same person (or place) to evaluate whether and to what extent context modulates human single-neuron responses. Nearly all neurons (97% during encoding and 100% during recall) initially responding to a person/place do not modulate their response with context. Likewise, nearly none (<1%) of the initially non-responsive neurons show conjunctive coding, responding to particular persons/places in a particular context during the tasks. In line with these findings, taking all neurons together it is possible to decode the person/place being depicted in each story, but not the particular story. Moreover, the neurons show consistent results across encoding and recall of the stories and during passive viewing of pictures. These results suggest a context invariant, non-conjunctive coding of memories at the single-neuron level in the human hippocampus and amygdala, in contrast to what has been described in other species.
- dc.format.mimetype application/pdf
- dc.identifier.citation Rey HG, Panagiotaropoulos TI, Gutierrez L, Chaure FJ, Nasimbera A, Cordisco S, Nishida F, Valentin A, Alarcon G, Richardson MP, Kochen S, Quian Quiroga R. Lack of context modulation in human single neuron responses in the medial temporal lobe. Cell Rep. 2025 Jan 28;44(1):115218. DOI: 10.1016/j.celrep.2024.115218
- dc.identifier.doi http://dx.doi.org/10.1016/j.celrep.2024.115218
- dc.identifier.issn 2211-1247
- dc.identifier.uri http://hdl.handle.net/10230/71656
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Cell Reports. 2025;44(1):115218
- dc.rights © 2025 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Memory
- dc.subject.keyword Human single-cell recordings
- dc.subject.keyword Hippocampus
- dc.subject.keyword Neural coding
- dc.subject.keyword Context modulation
- dc.subject.keyword Pattern separation
- dc.subject.keyword Human memory
- dc.subject.keyword Episodic memory
- dc.title Lack of context modulation in human single neuron responses in the medial temporal lobe
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion