Restraint-based three-dimensional modeling of genomes and genomic domains

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• dc.contributor.author Serra, Françoisca
• dc.contributor.author Di Stefano, Marcoca
• dc.contributor.author Spill, Yannick G.ca
• dc.contributor.author Cuartero, Yasminaca
• dc.contributor.author Goodstadt, Michaelca
• dc.contributor.author Baù, Davideca
• dc.contributor.author Martí Renom, Marc A.ca
• dc.date.accessioned 2016-07-22T13:36:18Z
• dc.date.issued 2015
• dc.description.abstract Chromosomes are large polymer molecules composed of nucleotides. In some species, such as humans, this polymer can sum up to meters long and still be properly folded within the nuclear space of few microns in size. The exact mechanisms of how the meters long DNA is folded into the nucleus, as well as how the regulatory machinery can access it, is to a large extend still a mystery. However, and thanks to newly developed molecular, genomic and computational approaches based on the Chromosome Conformation Capture (3C) technology, we are now obtaining insight on how genomes are spatially organized. Here we review a new family of computational approaches that aim at using 3C-based data to obtain spatial restraints for modeling genomes and genomic domains.ca
• dc.description.sponsorship We thank Michael Nilges for comments on standardization of data formats. We acknowledge support from the Spanish Ministerio de Economia y Competitividad [BFU2013–47736-P], the European Research Council [609989] and the Human Frontiers Science Program [RGP0044]
• dc.format.mimetype application/pdfca
• dc.identifier.citation Serra F, Di Stefano M, Spill YG, Cuartero Y, Goodstadt M, Baù D et al. Restraint-based three-dimensional modeling of genomes and genomic domains. FEBS Letters. 2015; 589(20 Pt A): 2987-2995. DOI 10.1016/j.febslet.2015.05.012ca
• dc.identifier.doi http://dx.doi.org/10.1016/j.febslet.2015.05.012
• dc.identifier.issn 0014-5793
• dc.identifier.uri http://hdl.handle.net/10230/27109
• dc.language.iso engca
• dc.publisher Wileyca
• dc.relation.ispartof FEBS Letters. 2015; 589(20 Pt A): 2987-2995
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/609989
• dc.rights This is the pre-peer reviewed version of the following article: Serra F, Di Stefano M, Spill YG, Cuartero Y, Goodstadt M, Baù D et al. Restraint-based three-dimensional modeling of genomes and genomic domains. FEBS Letters. 2015; 589(20 Pt A): 2987-2995. DOI 10.1016/j.febslet.2015.05.012, which has been published in final form at http://dx.doi.org/10.1016/j.febslet.2015.05.012. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.keyword 3D genome reconstruction
• dc.subject.keyword Chromosome Conformation Capture
• dc.subject.keyword Genome architecture
• dc.subject.keyword Restraint-based modeling
• dc.subject.other Cromosomesca
• dc.subject.other Regulació genèticaca
• dc.title Restraint-based three-dimensional modeling of genomes and genomic domainsca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/acceptedVersionca