Analysis of disease activity categories in chronic spontaneous/idiopathic urticarial

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  • dc.contributor.author Stull, Donaldca
  • dc.contributor.author McBride, Doreenca
  • dc.contributor.author Tian, H.ca
  • dc.contributor.author Giménez Arnau, Anna Mariaca
  • dc.contributor.author Maurer, Marcusca
  • dc.contributor.author Marsland, Alexanderca
  • dc.contributor.author Balp, Maria Magdalenaca
  • dc.contributor.author Khalil, Samca
  • dc.contributor.author Grattan, Cliveca
  • dc.date.accessioned 2017-11-27T08:41:56Z
  • dc.date.available 2017-11-27T08:41:56Z
  • dc.date.issued 2017
  • dc.description.abstract BACKGROUND: Measurement of disease activity guides treatment of chronic spontaneous urticaria (CSU). A weekly Urticaria Activity Score - here, the average of twice-daily patient assessment of itch and hives scores summed over 1 week (UAS7TD ) - measures severity from 0 to 42. Insufficient evidence exists on whether disease activity states, defined by categorical UAS7TD scores, correlate with other patient-reported outcomes and treatment response. OBJECTIVES: To evaluate and compare categorical UAS7TD scores with selected measures of disease-related quality of life and impact. METHODS: Data from three randomized clinical trials of omalizumab in CSU were pooled. Continuous UAS7TD scores were categorized into five disease activity states: urticaria-free, well-controlled, mild, moderate and severe urticaria. Total scores from the Dermatology Life Quality Index; the Chronic Urticaria Quality of Life questionnaire; and questions on sleep and daily activity interference, presence of angioedema and diphenhydramine use were compared within categorized UAS7TD disease-state scores, using anova for analysis at different time points and mixed-effects regressions for analysis of all data pooled. RESULTS: Pooled analyses showed that categorical UAS7TD disease states accurately predicted differences among treated patients with CSU with different levels of disease activity. A consistent pattern existed between categories, with higher-activity disease states associated with significantly higher impact and an increase in angioedema frequency. Results at different treatment time points were consistent. CONCLUSIONS: Categorical UAS7TD disease states can discriminate between measures when considering the impact of urticaria activity. Using five categorical disease states could simplify clinical assessment and monitoring of treatment efficacy.
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Stull D, McBride D, Tian H, Gimenez Arnau A, Maurer M, Marsland A. et al. Analysis of disease activity categories in chronic spontaneous/idiopathic urticarial. Br J Dermatol. 2017 Oct;177(4):1093-1101. DOI: 10.1111/bjd.15454
  • dc.identifier.doi http://dx.doi.org/10.1111/bjd.15454
  • dc.identifier.issn 0007-0963
  • dc.identifier.uri http://hdl.handle.net/10230/33338
  • dc.language.iso eng
  • dc.publisher Wileyca
  • dc.relation.ispartof British Journal of Dermatology. 2017 Oct;177(4):1093-1101
  • dc.rights © 2017 The Authors. British Journal of Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. This is an open access article under the terms of the https://creativecommons.org/licenses/by-nc-nd/4.0/ , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.other Urticària -- Tractament
  • dc.title Analysis of disease activity categories in chronic spontaneous/idiopathic urticarialca
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion