Epigallocatechin-3-gallate improves cardiac hypertrophy and short-term memory deficits in a Williams-Beuren syndrome mouse model

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Ortiz Romero, Paula, 1994-ca
• dc.contributor.author Borralleras Fumaña, Cristina, 1988-ca
• dc.contributor.author Bosch Morató, Mònica, 1986-ca
• dc.contributor.author Guivernau Almazán, Biuse, 1988-ca
• dc.contributor.author Albericio, Guillermoca
• dc.contributor.author Muñoz López, Francisco José, 1964-ca
• dc.contributor.author Pérez Jurado, Luis Albertoca
• dc.contributor.author Campuzano Uceda, María Victoriaca
• dc.date.accessioned 2018-04-05T07:45:27Z
• dc.date.available 2018-04-05T07:45:27Z
• dc.date.issued 2018
• dc.description.abstract Williams-Beuren syndrome (WBS) is a neurodevelopmental disorder caused by a heterozygous deletion of 26-28 genes at chromosome band 7q11.23. The complete deletion (CD) mouse model mimics the most common deletion found in WBS patients and recapitulates most neurologic features of the disorder along with some cardiovascular manifestations leading to significant cardiac hypertrophy with increased cardiomyocytes' size. Epigallocatechin-3-gallate (EGCG), the most abundant catechin found in green tea, has been associated with potential health benefits, both on cognition and cardiovascular phenotypes, through several mechanisms. We aimed to investigate the effects of green tea extracts on WBS-related phenotypes through a phase I clinical trial in mice. After feeding CD animals with green tea extracts dissolved in the drinking water, starting at three different time periods (prenatal, youth and adulthood), a set of behavioral tests and several anatomical, histological and molecular analyses were performed. Treatment resulted to be effective in the reduction of cardiac hypertrophy and was also able to ameliorate short-term memory deficits of CD mice. Taken together, these results suggest that EGCG might have a therapeutic and/or preventive role in the management of WBS.
• dc.description.sponsorship This work was supported by the Spanish Ministry of Economy and Competitiveness (grant SAF2012-40036, and SAF2016-78508-R(AEI/MINEICO/FEDER, UE) to VC; “Programa de Excelencia Maria de Maeztu” MDM-2014-0370, the Generalitat de Catalunya (2014SGR1468 and ICREA Acadèmia) to LAPJ; AGAUR FI-DGR/2013 fellowship to CB.
• dc.format.mimetype application/pdf
• dc.identifier.citation Ortiz-Romero P, Borralleras C, Bosch-Morató M, Guivernau B, Albericio G, Muñoz FJ et al. Epigallocatechin-3-gallate improves cardiac hypertrophy and short-term memory deficits in a Williams-Beuren syndrome mouse model. PLoS One. 2018 Mar 19;13(3):e0194476. DOI: 10.1371/journal.pone.0194476
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0194476
• dc.identifier.issn 1932-6203
• dc.identifier.uri http://hdl.handle.net/10230/34290
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)ca
• dc.relation.ispartof PLoS One. 2018 Mar 19;13(3):e0194476
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-40036
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-78508-R
• dc.rights © 2018 Ortiz-Romero et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Fluorescence imaging
• dc.subject.keyword Neuronal dendrites
• dc.subject.keyword Fluorescence microscopy
• dc.subject.keyword Cardiac hypertrophy
• dc.subject.keyword Williams-Beuren syndrome
• dc.title Epigallocatechin-3-gallate improves cardiac hypertrophy and short-term memory deficits in a Williams-Beuren syndrome mouse modelca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion