TANGO1 marshals the early secretory pathway for cargo export

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• dc.contributor.author Raote, Ishier
• dc.contributor.author Saxena, Sonashree
• dc.contributor.author Campelo, Felix
• dc.contributor.author Malhotra, Vivek
• dc.date.accessioned 2022-01-12T07:40:14Z
• dc.date.issued 2021
• dc.description.abstract TANGO1 protein facilitates the endoplasmic reticulum (ER) export of large cargoes that cannot be accommodated in 60 nm transport vesicles. It assembles into a ring in the plane of the ER membrane to create a distinct domain. Its lumenal portion collects and sorts folded cargoes while its cytoplasmic domains collar COPII coats, recruit retrograde COPI-coated membranes that fuse within the TANGO1 ring, thus opening a tunnel for cargo transfer from the ER into a growing export conduit. This mode of cargo transfer bypasses the need for vesicular intermediates and is used to export the most abundant and bulky cargoes. The evolution of TANGO1 and its activities defines the difference between yeast and animal early secretory pathways.
• dc.description.sponsorship Vivek Malhotra thanks Felix Goñi for keeping him sane in Spain. We acknowledge the Spanish Ministry of Science and Innovation for its support of the European Molecular Biology Laboratory partnership, the Centro de Excelencia Severo Ochoa, and the Centres de Recerca de Catalunya (CERCA) Programme/Generalitat de Catalunya. We acknowledge financial support from the following sources: Ministerio de Economía y Competitividad (SEV-2012-0208, BFU2013-44188-P, and CSD2009- 00016 to V.M. and IJCI-2017-34751 to I.R.). FC acknowledges support from the Government of Spain (RYC-2017-22227, PID2019-106232RB-I00/10.13039/501100011033; Severo Ochoa CEX2019-000910-S), Fundació Cellex, Fundació Mir-Puig, and Generalitat de Catalunya (CERCA, AGAUR).
• dc.format.mimetype application/pdf
• dc.identifier.citation Raote I, Saxena S, Campelo F, Malhotra V. TANGO1 marshals the early secretory pathway for cargo export. Biochim Biophys Acta Biomembr. 2021;1863(11):183700. DOI: 10.1016/j.bbamem.2021.183700
• dc.identifier.doi http://dx.doi.org/10.1016/j.bbamem.2021.183700
• dc.identifier.issn 0005-2736
• dc.identifier.uri http://hdl.handle.net/10230/52192
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Biochim Biophys Acta Biomembr. 2021;1863(11):183700
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2013-44188-P
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.bbamem.2021.183700
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword COPII
• dc.subject.keyword Chylomicron
• dc.subject.keyword Collagen
• dc.subject.keyword ER exit sites
• dc.subject.keyword Golgi
• dc.subject.keyword Mucins
• dc.subject.keyword Protein secretion
• dc.subject.keyword TALI
• dc.subject.keyword TANGO1
• dc.subject.keyword Vesicles
• dc.title TANGO1 marshals the early secretory pathway for cargo export
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion