Establishment of a non-Westernized gut microbiota in men who have sex with men is associated with sexual practices

Huang, Kun D.; Amend, Lena; Gálvez, Eric J. C.; Lesker, Till-Robin; Oliveira, Romulo de; Bielecka, Agata; Blanco-Míguez, Aitor; Vallès Colomer, Mireia; Ruf, Isabel; Pasolli, Edoardo; Buer, Jan; Segata, Nicola; Esser, Stefan; Strowig, Till; Kehrmann, Jan

Establishment of a non-Westernized gut microbiota in men who have sex with men is associated with sexual practices

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dc.contributor.author Huang, Kun D.
dc.contributor.author Amend, Lena
dc.contributor.author Gálvez, Eric J. C.
dc.contributor.author Lesker, Till-Robin
dc.contributor.author Oliveira, Romulo de
dc.contributor.author Bielecka, Agata
dc.contributor.author Blanco-Míguez, Aitor
dc.contributor.author Vallès Colomer, Mireia
dc.contributor.author Ruf, Isabel
dc.contributor.author Pasolli, Edoardo
dc.contributor.author Buer, Jan
dc.contributor.author Segata, Nicola
dc.contributor.author Esser, Stefan
dc.contributor.author Strowig, Till
dc.contributor.author Kehrmann, Jan
dc.date.accessioned 2024-04-18T05:45:40Z
dc.date.available 2024-04-18T05:45:40Z
dc.date.issued 2024
dc.description.abstract The human gut microbiota is influenced by various factors, including health status and environmental conditions, yet considerable inter-individual differences remain unexplained. Previous studies identified that the gut microbiota of men who have sex with men (MSM) is distinct from that of non-MSM. Here, we reveal through species-level microbiota analysis using shotgun metagenomics that the gut microbiota of many MSM with Western origin resembles gut microbial communities of non-Westernized populations. Specifically, MSM gut microbiomes are frequently dominated by members of the Prevotellaceae family, including co-colonization of species from the Segatella copri complex and unknown Prevotellaceae members. Questionnaire-based analysis exploring inter-individual differences in MSM links specific sexual practices to microbiota composition. Moreover, machine learning identifies microbial features associated with sexual activities in MSM. Together, this study shows associations of sexual activities with gut microbiome alterations in MSM, which may have a large impact on population-based microbiota studies.
dc.format.mimetype application/pdf
dc.identifier.citation Huang KD, Amend L, Gálvez EJC, Lesker TR, Oliveira R, Bielecka A, et al. Establishment of a non-Westernized gut microbiota in men who have sex with men is associated with sexual practices. Cell Rep Med. 2024 Mar 19;5(3):101426. DOI: 10.1016/j.xcrm.2024.101426
dc.identifier.doi http://dx.doi.org/10.1016/j.xcrm.2024.101426
dc.identifier.issn 2666-3791
dc.identifier.uri http://hdl.handle.net/10230/59814
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Cell Rep Med. 2024 Mar 19;5(3):101426
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword MSM
dc.subject.keyword Prevotella
dc.subject.keyword RAI
dc.subject.keyword Segatella
dc.subject.keyword Gut microbiome
dc.subject.keyword Non-Westernized microbiota
dc.subject.keyword Oral sex
dc.subject.keyword Sex partner
dc.subject.keyword Sexual orientation
dc.title Establishment of a non-Westernized gut microbiota in men who have sex with men is associated with sexual practices
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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