Similarity in recombination rate estimates highly correlates with genetic differentiation in humans
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- dc.contributor.author Laayouni, Hafid, 1968-ca
- dc.contributor.author Montanucci, Ludovica, 1978-ca
- dc.contributor.author Sikora, Martin, 1976-ca
- dc.contributor.author Melé Messeguer, Marta, 1982-ca
- dc.contributor.author Dall'Olio, Giovanni Marco, 1983-ca
- dc.contributor.author Lorente-Galdós, Belén, 1981-ca
- dc.contributor.author McGee, Kate Mca
- dc.contributor.author Graffelman, Janca
- dc.contributor.author Awadalla, Philipca
- dc.contributor.author Bosch Fusté, Elenaca
- dc.contributor.author Comas, David, 1969-ca
- dc.contributor.author Navarro i Cuartiellas, Arcadi, 1969-ca
- dc.contributor.author Calafell i Majó, Francescca
- dc.contributor.author Casals López, Ferranca
- dc.contributor.author Bertranpetit, Jaume, 1952-ca
- dc.date.accessioned 2015-04-30T07:11:25Z
- dc.date.available 2015-04-30T07:11:25Z
- dc.date.issued 2011ca
- dc.description.abstract Recombination varies greatly among species, as illustrated by the poor conservation of the recombination landscape between humans and chimpanzees. Thus, shorter evolutionary time frames are needed to understand the evolution of recombination. Here, we analyze its recent evolution in humans. We calculated the recombination rates between adjacent pairs of 636,933 common single-nucleotide polymorphism loci in 28 worldwide human populations and analyzed them in relation to genetic distances between populations. We found a strong and highly significant correlation between similarity in the recombination rates corrected for effective population size and genetic differentiation between populations. This correlation is observed at the genome-wide level, but also for each chromosome and when genetic distances and recombination similarities are calculated independently from different parts of the genome. Moreover, and more relevant, this relationship is robustly maintained when considering presence/absence of recombination hotspots. Simulations show that this correlation cannot be explained by biases in the inference of recombination rates caused by haplotype sharing among similar populations. This result indicates a rapid pace of evolution of recombination, within the time span of differentiation of modern humansen
- dc.description.sponsorship This research was funded by grants BFU2007-63657, BFU2009-13409-C02-02 and SAF-2007-63171 awarded by Ministerio de Educación y Ciencia (Spain), by the Direcció General de Recerca of Generalitat de Catalunya (Grup de Recerca Consolidat 2005SGR/00608 and 2009 SGR 1101), and by the National Institute for Bioinformatics (www.inab.org), a platform of Genoma España. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscripten
- dc.format.mimetype application/pdfca
- dc.identifier.citation Laayouni H, Montanucci L, Sikora M, Mele M, Dall'Olio GM, Lorente-Galdos B et al. Similarity in recombination rate estimates highly correlates with genetic differentiation in humans. PLoS ONE. 2011;6(3):e17913. DOI: 10.1371/journal.pone.0017913ca
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0017913
- dc.identifier.issn 1932-6203ca
- dc.identifier.uri http://hdl.handle.net/10230/23500
- dc.language.iso engca
- dc.publisher Public Library of Science (PLoS)ca
- dc.relation.ispartof PLoS ONE. 2011;6(3):e17913
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/BFU2007-63657
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/SAF2007-63171
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2009-13409
- dc.rights © 2011 Laayouni et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Genètica de poblacions humanesca
- dc.subject.other Genètica evolutivaca
- dc.title Similarity in recombination rate estimates highly correlates with genetic differentiation in humansca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca